POU6F2 - POU class 6 homeobox 2 Gene

Homo sapiens

Also known as WT5; WTSL; RPF-1

Gene ID: 11281 | Gene type: protein coding

About POU6F2

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:38,977,909-39,468,601 (from NCBI)

This gene has 12 transcripts (splice variants), 218 orthologues, 17 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

POU6F2 Products(3)

mRNA	Protein	Name
NM_001166018.2	NP_001159490.1	POU domain, class 6, transcription factor 2 isoform 2
NM_001370959.1	NP_001357888.1	POU domain, class 6, transcription factor 2 isoform 3
NM_007252.4	NP_009183.3	POU domain, class 6, transcription factor 2 isoform 1

POU6F2 Protein Structure

Pou

Homeobox

0
200
400
600
691 a.a.

Protein Preferred Names

Protein Names

POU domain, class 6, transcription factor 2

Wilms tumor suppressor locus

Related Diseases

Diseases

Alias

Wilms Tumor 5

Wilms Tumor	WT5
Wilms Tumor Susceptibility-5	Wilms Tumor And Radial Bilateral Aplasia
Nephroblastoma	Wilms' Tumor
Wilms Tumor, Susceptibility To	Wtsl
Bilateral Radial Aplasia With Wilms Tumor	Embryonal Adenosarcoma
Embryonal Nephroma	Kidney Wilms Tumor
Kidney, Adenomyosarcoma, Embryonal	Kidney, Carcinosarcoma, Embryonal
Kidney, Embryoma	Kidney, Embryonal Mixed Tumor
Nephroma	Renal Adenosarcoma
Renal Cancer, Wilms	Renal Wilms Tumor
Tumor, Wilms	Hereditary Susceptibility To Wilms Tumor 5

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type

Wilson-Turner Syndrome	WTS
Mrxs6	X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome
Mrxswt	Wilson-Turner X-Linked Mental Retardation Syndrome
Mental Retardation, X-Linked, Syndromic 6	Mental Retardation, X-Linked, With Gynecomastia And Obesity
Intellectual Disability, X-Linked, Syndromic 6	Intellectual Disability, X-Linked, With Gynecomastia And Obesity
Wilson Turner Intellectual Disability Syndrome	X-Linked Intellectual Disability - Gynecomastia - Obesity

Syndromic X-Linked Intellectual Disability

X-Linked Syndromic Intellectual Disability

Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10913	POU6F2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	POU6F2	VGNC	VGNC:76093
Rattus norvegicus	POU6F2	RGD	RGD:1584652
Felis catus	POU6F2	VGNC	VGNC:102664
Mus musculus	POU6F2	MGD	MGI:2443631

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