2. Gene
  3. PLCD3 - phospholipase C delta 3 Gene

PLCD3 - phospholipase C delta 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PLC-delta-3

Gene ID: 113026 | Gene type: protein coding

About PLCD3

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,108,959-45,132,515 (from NCBI)

This gene has 12 transcripts (splice variants), 292 orthologues and 14 paralogues. Broad expression in colon (RPKM 22.8), urinary bladder (RPKM 21.5) and 20 other tissues.

Summary

This gene encodes a member of the Phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This Enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several Phospholipids. [provided by RefSeq, Jul 2008]

PLCD3 Products(1)

mRNA Protein Name
NM_133373.5 NP_588614.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

PLCD3 Protein Structure

EF-hand_10

EF-hand_10: EF hand (201 - 250)

EF-hand_like

EF-hand_like: Phosphoinositide-specific phospholipase C, efhand-like (255 - 335)

PI-PLC-X

PI-PLC-X: Phosphatidylinositol-specific phospholipase C, X domain (339 - 483)

PI-PLC-Y

PI-PLC-Y: Phosphatidylinositol-specific phospholipase C, Y domain (527 - 643)

C2

C2: C2 domain (661 - 750)

  • 0
  • 200
  • 400
  • 600
  • 788 a.a.
Protein Preferred Names Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3

Related Diseases

Diseases Alias
Adult Pineal Parenchymal Tumor

Adult Pineal Parenchymal Neoplasm
Adult Pineoblastoma
Craniofacial Microsomia

Goldenhar Syndrome

Hemifacial Microsomia

Oculoauriculovertebral Spectrum

Oavs

Oculo-Auriculo-Vertebral Spectrum

CFM

Oav Dysplasia

Facioauriculovertebral Sequence

Fav Sequence

First And Second Branchial Arch Syndrome

Otomandibular Dysostosis

Hfm

Oculoauriculovertebral Dysplasia

Facio-Auriculo-Vertebral Spectrum

Facioauriculovertebral Dysplasia

Oculo-Auriculo-Vertebral Dysplasia

First Arch Syndrome

Oav Dysplasia

Goldenhar Disease

Expanded Spectrum Hemifacial Microsomia

Expanded Spectrum Of Hemifacial Microsomia

Oculoauriculovertebral Syndrome

Oavd

Asymmetric Hypoplasia Of Facial Structures

Auriculobranchiogenic Dysplasia

Fav

First And Second Pharyngeal Arch Syndromes

Goldenhar-Gorlin Syndrome

Lateral Facial Dysplasia

Oav Complex

Oral-Mandibular-Auricular Syndrome

Unilateral Intrauterine Facial Necrosis

Unilateral Mandibulofacial Dysostosis

Oav Spectrum

Oculoauricular Vertebral Dysplasia

Microsomia, Hemifacial

Goldenhar Syndrome With Ipsilateral Radial Defect
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10657 PLCD3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PLCD3 MGD MGI:107451
Bos taurus PLCD3 VGNC VGNC:32985
Rattus norvegicus PLCD3 RGD RGD:1310903
Macaca mulatta PLCD3 VGNC VGNC:99205
Felis catus PLCD3 VGNC VGNC:68897
Canis familiaris PLCD3 VGNC VGNC:44648