VSIG4 - V-set and immunoglobulin domain containing 4 Gene

Homo sapiens

Also known as CRIg; Z39IG

Gene ID: 11326 | Gene type: protein coding

About VSIG4

Cytogenetic location: Xq12 Genomic coordinates (GRCh38): X:66,021,738-66,040,080 (from NCBI)

This gene has 5 transcripts (splice variants) and 121 orthologues. Broad expression in placenta (RPKM 50.4), lung (RPKM 39.9) and 19 other tissues.

Summary

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the Complement Component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

VSIG4 Products(5)

mRNA	Protein	Name
NM_001100431.2	NP_001093901.1	V-set and immunoglobulin domain-containing protein 4 isoform 2 precursor
NM_001184830.2	NP_001171759.1	V-set and immunoglobulin domain-containing protein 4 isoform 4 precursor
NM_001184831.2	NP_001171760.1	V-set and immunoglobulin domain-containing protein 4 isoform 3 precursor
NM_001257403.2	NP_001244332.1	V-set and immunoglobulin domain-containing protein 4 isoform 5 precursor
NM_007268.3	NP_009199.1	V-set and immunoglobulin domain-containing protein 4 isoform 1 precursor

VSIG4 Protein Structure

V-set

Ig_3

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

V-set and immunoglobulin domain-containing protein 4

Ig superfamily protein

Recombinant VSIG4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71423	VSIG4 Protein, Human (HEK293, Fc)	Q9Y279 (R20-V284)	≥95%
HY-P71424	VSIG4 Protein, Human (264a.a, HEK293, His)	Q9Y279 (R20-P283)	≥95%
HY-P74465	VSIG4 Protein, Human (283a.a, HEK293, His)	Q9Y279 (R20-P283)	≥95%

Related Diseases

Diseases

Alias

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Diamond-Blackfan Anemia 1

Aase Syndrome	DBA1
Erythrogenesis Imperfecta	Aase-Smith Syndrome Ii
Dba	Blackfan-Diamond Syndrome
Bds	Anemia, Congenital Hypoplastic, Of Blackfan And Diamond
Anemia, Congenital Erythroid Hypoplastic	Red Cell Aplasia, Pure, Hereditary
Aregenerative Anemia, Chronic Congenital	Rps19-Related Diamond-Blackfan Anemia
Chronic Congenital Aregenerative Anemia	Congenital Erythroid Hypoplastic Anemia
Congenital Hypoplastic Anemia Of Blackfan And Diamond	Pure Hereditary Red Cell Aplasia
Anemia, Diamond-Blackfan, Type 1	Anemia, Diamond-Blackfan
Aase Smith Syndrome 2	Familial Hypoplastic Anaemia With Malformations
Constitutional Pure Red Cell Aplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15709	VSIG4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	VSIG4	RGD	RGD:1564659
Macaca mulatta	VSIG4	VGNC	VGNC:79062
Mus musculus	VSIG4	MGD	MGI:2679720
Bos taurus	VSIG4	VGNC	VGNC:36840
Canis familiaris	VSIG4	VGNC	VGNC:48308
Felis catus	VSIG4	VGNC	VGNC:66978
Macaca fascicularis	VSIG4	NCBI
Others	VSIG4	NCBI

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