ACOT7 - acyl-CoA thioesterase 7 Gene

Homo sapiens

Also known as ACT; ACH1; BACH; LACH; LACH1; hBACH; CTE-II

Gene ID: 11332 | Gene type: protein coding

About ACOT7

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,264,272-6,393,767 (from NCBI)

This gene has 10 transcripts (splice variants), 194 orthologues and 2 paralogues. Broad expression in brain (RPKM 26.5), kidney (RPKM 21.3) and 22 other tissues.

Summary

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]

ACOT7 Products(4)

mRNA	Protein	Name
NM_007274.4	NP_009205.3	cytosolic acyl coenzyme A thioester hydrolase isoform hBACHa
NM_181864.3	NP_863654.1	cytosolic acyl coenzyme A thioester hydrolase isoform hBACHb
NM_181865.3	NP_863655.1	cytosolic acyl coenzyme A thioester hydrolase isoform hBACHc
NM_181866.3	NP_863656.1	cytosolic acyl coenzyme A thioester hydrolase isoform hBACHd

ACOT7 Protein Structure

4HBT

0
100
200
300
380 a.a.

Protein Preferred Names

Protein Names

cytosolic acyl coenzyme A thioester hydrolase

CTE-IIa

Related Diseases

Diseases

Alias

Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Hyperinsulinemic Hypoglycemia, Familial, 7

HHF7	Exercise-Induced Hyperinsulinemic Hypoglycemia
Exercise-Induced Hyperinsulinism	Familial Hyperinsulinemic Hypoglycemia 7
Eihi	Hyperinsulinism Due To Monocarboxylate Transporter 1 Deficiency
Hyperinsulinism Due To Slc16a1 Deficiency	Hyperinsulinemic Hypoglycemia, Exercise-Induced
Exercise Induced Hyperinsulinemic Hypoglycemia	Hyperinsulinemic Hypoglycemia Exercise-Induced
Hyperinsulinemic Hypoglycemia Familial 7

Pontocerebellar Hypoplasia, Type 16

PCH16	Pontocerebellar Hypoplasia Type 16
Pontocerebellar Hypoplasia 16	Doid:0112333

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00179	ACOT7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ACOT7	RGD	RGD:628856
Canis familiaris	ACOT7	VGNC	VGNC:53259
Felis catus	ACOT7	VGNC	VGNC:82524
Macaca mulatta	ACOT7	VGNC	VGNC:99835
Mus musculus	ACOT7	MGD	MGI:1917275

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