HENMT1 - HEN methyltransferase 1 Gene

Homo sapiens

Also known as HEN1; C1orf59

Gene ID: 113802 | Gene type: protein coding

About HENMT1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:108,648,295-108,661,474 (from NCBI)

This gene has 7 transcripts (splice variants) and 199 orthologues. Biased expression in testis (RPKM 38.3), lymph node (RPKM 5.6) and 13 other tissues.

Summary

Enables small RNA 2'-O-methyltransferase. Involved in RNA methylation. Predicted to be located in P granule. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

HENMT1 Products(2)

mRNA	Protein	Name
NM_001102592.2	NP_001096062.1	small RNA 2'-O-methyltransferase
NM_144584.3	NP_653185.2	small RNA 2'-O-methyltransferase

HENMT1 Protein Structure

Methyltransf_23

0
100
200
300
393 a.a.

Protein Preferred Names

Protein Names

small RNA 2'-O-methyltransferase

HEN1 methyltransferase homolog 1

Related Diseases

Diseases

Alias

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06121	HENMT1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HENMT1	VGNC	VGNC:73241
Bos taurus	HENMT1	VGNC	VGNC:29809
Mus musculus	HENMT1	MGD	MGI:1913965
Rattus norvegicus	HENMT1	RGD	RGD:1306230
Felis catus	HENMT1	VGNC	VGNC:62795
Canis familiaris	HENMT1	VGNC	VGNC:41656

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