CGB2 - chorionic gonadotropin subunit beta 2 Gene

Homo sapiens

Gene ID: 114336 | Gene type: protein coding

About CGB2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,031,890-49,033,238 (from NCBI)

This gene has 2 transcripts (splice variants), 36 orthologues and 9 paralogues. Restricted expression toward placenta (RPKM 15.8).

Summary

The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]

CGB2 Products(2)

mRNA	Protein	Name
NM_001319065.2	NP_001305994.1	choriogonadotropin subunit beta variant 2 isoform 2
NM_033378.2	NP_203696.2	choriogonadotropin subunit beta variant 2 isoform 1 precursor

CGB2 Protein Structure

Cys_knot

0
100
163 a.a.

Protein Preferred Names

Protein Names

choriogonadotropin subunit beta variant 2

chorionic gonadotropin beta subunit 2

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02580	CGB2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CGB2	MGD	MGI:96782