2. Gene
  3. Adk - adenosine kinase Gene

Adk - adenosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ak; 2310026J05Rik; 5033405D03Rik

Gene ID: 11534 | Gene type: protein coding

About Adk

Chromosome 14: 21,102,642-21,498,637 forward strand.GRCm39:CM001007.3

This gene has 10 transcripts (splice variants), 275 orthologues, 3 paralogues and is associated with 34 phenotypes. Broad expression in liver adult (RPKM 33.3), liver E18 (RPKM 24.2) and 21 other tissues.

Summary

Enables Adenosine Kinase activity and deoxyadenosine kinase activity. Involved in AMP salvage; GMP salvage; and dAMP salvage. Acts upstream of or within dATP biosynthetic process and purine ribonucleoside salvage. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in hypermethioninemia due to Adenosine Kinase deficiency. Orthologous to human ADK (Adenosine Kinase). [provided by Alliance of Genome Resources, Apr 2022]

Adk Products(2)

mRNA Protein Name
NM_134079.4 NP_598840.1 adenosine kinase isoform 1
NM_001243041.1 NP_001229970.1 adenosine kinase isoform 2

Adk Protein Structure

ribokinase_pfkB_like

ribokinase_pfkB_like: cl00192 (27 - 359)

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  • 361 a.a.
Protein Preferred Names Protein Names

adenosine kinase

adenosine 5'-phosphotransferase

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P2952 Adenylate / Unkown
HY-RS00383 ADK Human Pre-designed siRNA Set A / Unkown
HY-RS00384 Adk Mouse Pre-designed siRNA Set A / Unkown
HY-RS00385 Adk Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adk NCBI NCBI:132