LYPD1 - LY6/PLAUR domain containing 1 Gene

Homo sapiens

Also known as PHTS; LYPDC1

Gene ID: 116372 | Gene type: protein coding

About LYPD1

Cytogenetic location: 2q21.2 Genomic coordinates (GRCh38): 2:132,643,286-132,671,526 (from NCBI)

This gene has 3 transcripts (splice variants), 249 orthologues and 3 paralogues. Broad expression in brain (RPKM 4.3), colon (RPKM 1.3) and 16 other tissues.

Summary

Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to act upstream of or within several processes, including behavioral fear response; cholinergic synaptic transmission; and negative regulation of protein localization to plasma membrane. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

LYPD1 Products(4)

mRNA	Protein	Name
NM_001077427.4	NP_001070895.1	ly6/PLAUR domain-containing protein 1 isoform b
NM_001321234.2	NP_001308163.1	ly6/PLAUR domain-containing protein 1 isoform c
NM_001321235.2	NP_001308164.1	ly6/PLAUR domain-containing protein 1 isoform b
NM_144586.7	NP_653187.3	ly6/PLAUR domain-containing protein 1 isoform a precursor

Protein Preferred Names

Protein Names

ly6/PLAUR domain-containing protein 1

putative HeLa tumor suppressor

Related Diseases

Diseases

Alias

Arthrogryposis, Distal, Type 2a

Freeman-Sheldon Syndrome	Craniocarpotarsal Dystrophy
Craniocarpotarsal Dysplasia	DA2A
Whistling Face-Windmill Vane Hand Syndrome	Fss
Distal Arthrogryposis Type 2a	Whistling Face Syndrome
Freeman-Burian Syndrome	Arthrogryposis Distal Type 2a
Distal Arthrogryposis, Type 2a	Fbs
Arthrogryposis, Distal, 2a

Melanotic Medulloblastoma

Medulloblastoma, Melanotic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07915	LYPD1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LYPD1	RGD	RGD:1549754
Macaca mulatta	LYPD1	VGNC	VGNC:104542
Felis catus	LYPD1	VGNC	VGNC:63339
Mus musculus	LYPD1	MGD	MGI:1919835
Canis familiaris	LYPD1	VGNC	VGNC:42883
Bos taurus	LYPD1	VGNC	VGNC:31099

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