Ccr3 - C-C motif chemokine receptor 3 Gene

Rattus norvegicus

Also known as Cmkbr3

Gene ID: 117027 | Gene type: protein coding

About Ccr3

Primary_assembly 8: 123,616,236-123,634,990 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 142 orthologues, 24 paralogues and is associated with 40 phenotypes. Biased expression in Spleen (RPKM 24.1) and Uterus (RPKM 12.4).

Summary

Predicted to enable C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in ERK1 and ERK2 cascade; angioblast cell migration; and leukocyte chemotaxis. Located in endosome; extracellular space; and plasma membrane. Used to study asthma and myocardial infarction. Biomarker of rhinitis. Human ortholog(s) of this gene implicated in asthma; ovary epithelial cancer; and rhinitis. Orthologous to human CCR3 (C-C motif Chemokine Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ccr3 Products(1)

mRNA	Protein	Name
NM_053958.2	NP_446410.1	C-C chemokine receptor type 3

Ccr3 Protein Structure

7tmA_CCR3

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor type 3

C-C CKR-3	CC-CKR-3
CCR-3	CKR3
chemokine (C-C motif) receptor 3	chemokine (C-C) receptor 3

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-136788	ALK4290	Inhibitor	99.21%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107051	GW 766994	Antagonist	98.77%	Unkown
HY-103360	J-113863	Antagonist	≥99.0%	Unkown
HY-103363	SB-328437	Antagonist	98.48%	Unkown
HY-P3982	CKLF1-C19	Chemical	99.95%	Unkown
HY-U00331	CCR3 antagonist 1	Antagonist	98.95%	Unkown
HY-120629	BMS-639623	Antagonist	/	Unkown
HY-N10397	Maceneolignan H	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr3	NCBI	NCBI:1232

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