CLIC1 - chloride intracellular channel 1 Gene

Homo sapiens

Also known as G6; CL1C1; NCC27; CLCNL1

Gene ID: 1192 | Gene type: protein coding

About CLIC1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,730,581-31,737,318 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 249 orthologues and 14 paralogues. Ubiquitous expression in placenta (RPKM 110.8), bone marrow (RPKM 106.5) and 25 other tissues.

Summary

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

CLIC1 Products(3)

mRNA	Protein	Name
NM_001287593.1	NP_001274522.1	chloride intracellular channel protein 1
NM_001287594.3	NP_001274523.1	chloride intracellular channel protein 1
NM_001288.6	NP_001279.2	chloride intracellular channel protein 1

CLIC1 Protein Structure

GST_N_3

GST_C_2

0
100
200
241 a.a.

Protein Preferred Names

Protein Names

chloride intracellular channel protein 1

RNCC protein

Recombinant CLIC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7840	CLIC1 Protein, Human (His)	O00299 (M1-K241)	≥95%
HY-P7840A	CLIC1 Protein, Human (N-His)	O00299 (A2-K241)	≥95%

Related Diseases

Diseases

Alias

Intrahepatic Gall Duct Cancer

Malignant Neoplasm Of Intrahepatic Bile Ducts	Malignant Neoplasm Of Intrahepatic Gall Duct
Ca Intrahepatic Bile Ducts	Malignant Neoplasm Of Intrahepatic Biliary Passages
Intrahepatic Bile Duct Carcinoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12693A	(Rac)-Methylindazone		/	Unkown
HY-RS02803	CLIC1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CLIC1	MGD	MGI:2148924
Rattus norvegicus	CLIC1	RGD	RGD:1303043
Bos taurus	CLIC1	VGNC	VGNC:27439
Felis catus	CLIC1	VGNC	VGNC:60959
Others	CLIC1	NCBI

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