FAT3 - FAT atypical cadherin 3 Gene

Homo sapiens

Also known as hFat3; CDHF15; CDHR10

Gene ID: 120114 | Gene type: protein coding

About FAT3

Cytogenetic location: 11q14.3 Genomic coordinates (GRCh38): 11:92,224,818-92,896,473 (from NCBI)

This gene has 6 transcripts (splice variants), 317 orthologues, 6 paralogues and is associated with 124 phenotypes. Biased expression in brain (RPKM 1.5), prostate (RPKM 0.4) and 7 other tissues.

Summary

Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within several processes, including negative regulation of dendrite development; neuron migration; and retina layer formation. Predicted to be located in dendrite and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

FAT3 Products(3)

mRNA	Protein	Name
NM_001008781.3	NP_001008781.2	protocadherin Fat 3 isoform 2 precursor
NM_001367949.2	NP_001354878.1	protocadherin Fat 3 isoform 1 precursor
NM_001378141.1	NP_001365070.1	protocadherin Fat 3 isoform 3 precursor

FAT3 Protein Structure

Cadherin

Laminin_G_2

EGF_CA

0
800
1600
2400
3200
4000
4589 a.a.

Protein Preferred Names

Protein Names

protocadherin Fat 3

FAT tumor suppressor homolog 3

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 45

SCA45

Spinocerebellar Ataxia Type 45

Classic Pulmonary Blastoma

Biphasic Pulmonary Blastoma

Van Maldergem Syndrome

Van Maldergem Wetzburger Verloes Syndrome	Cerebro-Facio-Articular Syndrome
Cerebro-Facio-Articular Syndrome Of Van Maldergem	Cerebrofacioarticular Syndrome
Cerebro Facio Articular Syndrome	Van Maldergem-Wetzburger-Verloes Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04762	FAT3 Human Pre-designed siRNA Set A		/	Unkown
HY-W009544	3-Hydroxytetradecanoic acid		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FAT3	MGD	MGI:2444314
Canis familiaris	FAT3	VGNC	VGNC:40744
Felis catus	FAT3	VGNC	VGNC:62159
Bos taurus	FAT3	VGNC	VGNC:28876
Rattus norvegicus	FAT3	RGD	RGD:620657

Name
Email *

	Sorry, but the email address you supplied was invalid.