2. Gene
  3. SPATA18 - spermatogenesis associated 18 Gene

SPATA18 - spermatogenesis associated 18 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Mieap; SPETEX1

Gene ID: 132671 | Gene type: protein coding

About SPATA18

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:52,051,304-52,097,299 (from NCBI)

This gene has 10 transcripts (splice variants) and 222 orthologues. Broad expression in testis (RPKM 22.6), lung (RPKM 5.4) and 14 other tissues.

Summary

This gene encodes a p53-inducible protein that is able to induce lysosome-like organelles within mitochondria that eliminate oxidized mitochondrial proteins, thereby contributing to mitochondrial quality control. Dysregulation of mitochondrial quality control is associated with Cancer and degenerative diseases. The encoded protein mediates accumulation of the lysosome-like mitochondrial organelles through interaction with B cell lymphoma 2 interacting protein 3 and B cell lymphoma 2 interacting protein 3 like at the outer mitochondrial membrane, which allows translocation of lysosomal proteins to the mitochondrial matrix from the cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

SPATA18 Products(4)

mRNA Protein Name
NM_001297608.2 NP_001284537.1 mitochondria-eating protein isoform 2
NM_001346102.2 NP_001333031.1 mitochondria-eating protein isoform 3 precursor
NM_001346103.2 NP_001333032.1 mitochondria-eating protein isoform 4
NM_145263.4 NP_660306.1 mitochondria-eating protein isoform 1
Protein Preferred Names Protein Names

mitochondria-eating protein

spermatogenesis associated 18 homolog

Related Diseases

Diseases Alias
Bronchus Cancer

Malignant Neoplasm Of Bronchus And Lung

Bronchus Carcinoma

Bronchogenic Carcinoma

Malignant Neoplasm Of Bronchus Or Lung

Bc - Bronchogenic Carcinoma

Carcinoma, Bronchogenic

Bronchial Neoplasms
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13638 SPATA18 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SPATA18 MGD MGI:1920722
Bos taurus SPATA18 VGNC VGNC:35176
Rattus norvegicus SPATA18 RGD RGD:735208
Canis familiaris SPATA18 VGNC VGNC:46706
Felis catus SPATA18 VGNC VGNC:80009
Macaca mulatta SPATA18 VGNC VGNC:78013