STARD4 - StAR related lipid transfer domain containing 4 Gene

Homo sapiens

Gene ID: 134429 | Gene type: protein coding

About STARD4

Cytogenetic location: 5q22.1 Genomic coordinates (GRCh38): 5:111,496,033-111,512,535 (from NCBI)

This gene has 12 transcripts (splice variants), 162 orthologues and 5 paralogues. Ubiquitous expression in duodenum (RPKM 9.8), small intestine (RPKM 9.3) and 22 other tissues.

Summary

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in Cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]

STARD4 Products(7)

mRNA	Protein	Name
NM_001308056.2	NP_001294985.1	stAR-related lipid transfer protein 4 isoform a
NM_001308057.2	NP_001294986.1	stAR-related lipid transfer protein 4 isoform b
NM_001308058.2	NP_001294987.1	stAR-related lipid transfer protein 4 isoform b
NM_001308059.2	NP_001294988.1	stAR-related lipid transfer protein 4 isoform c
NM_001308060.2	NP_001294989.1	stAR-related lipid transfer protein 4 isoform d
NM_001308061.2	NP_001294990.1	stAR-related lipid transfer protein 4 isoform c
NM_139164.3	NP_631903.1	stAR-related lipid transfer protein 4 isoform a

STARD4 Protein Structure

START

0
100
205 a.a.

Protein Preferred Names

Protein Names

stAR-related lipid transfer protein 4

START domain containing 4, sterol regulated

Related Diseases

Diseases

Alias

Lipoid Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia	Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Congenital Lipoid Adrenal Hyperplasia	Lipoid Cah
Lipoid Adrenal Hyperplasia	Adrenal Hyperplasia 1
Cah	Clah
LCAH	Adrenal Hyperplasia I
Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism	Congenital Adrenal Hyperplasia Lipoid
Adrenal Hyperplasia, Congenital	Congenital Adrenal Hyperplasia, Lipoid
AH1	Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism
Adrenal Hyperplasia Congenital	Hyperplasia, Adrenal, Lipoid, Congenital
Congenital Adrenogenital Disorders Associated With Enzyme Deficiency	Congenital Adrenal Cortical Hyperplasia
Congenital Adrenal Gland Hyperplasia	Congenital Adrenogenital Syndrome
Congenital Hyperadrenocorticism	Congenital Adrenogenitalism
Congenital Female Adrenal Pseudohermaphroditism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13880	STARD4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	STARD4	VGNC	VGNC:102336
Canis familiaris	STARD4	VGNC	VGNC:46884
Macaca mulatta	STARD4	VGNC	VGNC:77947
Rattus norvegicus	STARD4	RGD	RGD:1309475
Mus musculus	STARD4	MGD	MGI:2156764
Bos taurus	STARD4	VGNC	VGNC:35365

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