UPRT - uracil phosphoribosyltransferase homolog Gene

Homo sapiens

Also known as UPP; FUR1

Gene ID: 139596 | Gene type: protein coding

About UPRT

Cytogenetic location: Xq13.3 Genomic coordinates (GRCh38): X:75,156,369-75,304,897 (from NCBI)

This gene has 9 transcripts (splice variants), 217 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 3.5), thyroid (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The Enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and Cancer. [provided by RefSeq, Nov 2009]

UPRT Products(3)

mRNA	Protein	Name
NM_001307944.1	NP_001294873.1	uracil phosphoribosyltransferase homolog isoform 2
NM_001363821.1	NP_001350750.1	uracil phosphoribosyltransferase homolog isoform 3
NM_145052.4	NP_659489.1	uracil phosphoribosyltransferase homolog isoform 1

UPRT Protein Structure

UPRTase

0
100
200
309 a.a.

Protein Preferred Names

Protein Names

uracil phosphoribosyltransferase homolog

RP11-311P8.3

Recombinant UPRT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71417	UPRT Protein, Human (His)	Q96BW1 (M1-D309)	≥95%

Related Diseases

Diseases

Alias

Geotrichosis

Breast Fibrosarcoma

Fibrosarcoma Of The Breast

Congenital Toxoplasmosis

Toxoplasmosis, Congenital	Mother-To-Child Transmission Of Toxoplasmosis
Toxoplasma Embryofetopathy	Toxoplasma Embryopathy
Toxoplasmosis - Congen.	Toxoplasmosis Congenital

Coccidiosis

Intestinal Coccidiosis

Enteric Coccidiosis

Hemophagocytic Lymphohistiocytosis, Familial, 3

Familial Hemophagocytic Lymphohistiocytosis 3	FHL3
Hplh3	Hlh3
Lymphohistiocytosis, Hemophagocytic, Familial, Type 3

Orotic Aciduria

Hereditary Orotic Aciduria	Orotidylic Pyrophosphorylase And Orotidylic Decarboxylase Deficiency
Uridine Monophosphate Synthase Deficiency	Umps Deficiency
Uridine Monophosphate Synthetase Deficiency	Orotic Aciduria I
Orotate Phosphoribosyltransferase And Orotidylic Decarboxylase Deficiency	Oprt And Odc Deficiency
Ump Synthase Deficiency	Orotic Aciduria Ii
Oroticaciduria 1	Orotic Aciduria Hereditary
Orotic Aciduria Type 1	Hereditary Orotic Aciduria Without Megaloblastic Anemia
Orotate Phosphoribosyltransferase And Omp Decarboxylase Deficiency	Ump Synthtase Deficiency
Umps	Orotidylic Decarboxylase Deficiency
Orotic Aciduria 1	ORAC1
Aciduria, Orotic	Hereditary Orotic Aciduria, Type 1
Orotic Aciduria Nos	Orotaciduric Anaemia
Orotic Aciduria Anaemia	Orotic Aciduria Megaloblastic Anaemia

Cryptosporidiosis

Cryptosporidial Gastroenteritis	Intestinal Cryptosporidiosis
Infection By Cryptosporidium	Gastroenteritis Due To Cryptosporidium
Cryptosporidial Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15492	UPRT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	UPRT	VGNC	VGNC:48158
Rattus norvegicus	UPRT	RGD	RGD:1564806
Bos taurus	UPRT	VGNC	VGNC:36690
Macaca mulatta	UPRT	VGNC	VGNC:81601
Mus musculus	UPRT	MGD	MGI:2685620
Felis catus	UPRT	VGNC	VGNC:97679
Others	UPRT	NCBI