CRY2 - cryptochrome circadian regulator 2 Gene

Homo sapiens

Also known as HCRY2; PHLL2

Gene ID: 1408 | Gene type: protein coding

About CRY2

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:45,847,118-45,883,244 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 24.1), brain (RPKM 22.3) and 25 other tissues.

Summary

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across Plants and Animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

CRY2 Products(2)

mRNA	Protein	Name
NM_001127457.3	NP_001120929.1	cryptochrome-2 isoform 2
NM_021117.5	NP_066940.3	cryptochrome-2 isoform 1

CRY2 Protein Structure

DNA_photolyase

FAD_binding_7

0
100
200
300
400
500
614 a.a.

Protein Preferred Names

Protein Names

cryptochrome-2

cryptochrome 2 (photolyase-like)

Related Diseases

Diseases

Alias

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Dysthymic Disorder

Dysthymia	Chronic Depressive Disorder
Chronic Depression	Depressive Personality
Depressive Personality Disorder	Persistent Depressive Disorder
Persistent Depression

Diabetes Mellitus

Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0318	Metronidazole		99.92%	Yes
HY-B0318A	Metronidazole hydrochloride		/	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-108468	KL001	99.68%	Unkown
HY-115672	KS15	99.40%	Unkown
HY-134194	KL201	98.15%	Unkown
HY-RS03205	CRY2 Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CRY2	VGNC	VGNC:27731
Canis familiaris	CRY2	VGNC	VGNC:39634
Mus musculus	CRY2	MGD	MGI:1270859
Felis catus	CRY2	VGNC	VGNC:61196
Rattus norvegicus	CRY2	RGD	RGD:620935
Macaca mulatta	CRY2	VGNC	VGNC:71500

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