2. Gene
  3. CST11 - cystatin 11 Gene

CST11 - cystatin 11 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SC13; CST8L; CTES2; dJ322G13.6

Gene ID: 140880 | Gene type: protein coding

About CST11

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,450,412-23,452,876 (from NCBI)

This gene has 2 transcripts (splice variants), 150 orthologues and 11 paralogues. Low expression observed in reference dataset.

Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014]

CST11 Products(2)

mRNA Protein Name
NM_080830.3 NP_543020.2 cystatin-11 isoform 2 precursor
NM_130794.2 NP_570612.1 cystatin-11 isoform 1 precursor

CST11 Protein Structure

Cystatin

Cystatin: Cystatin domain (44 - 124)

  • 0
  • 100
  • 138 a.a.
Protein Preferred Names Protein Names

cystatin-11

SC13delta

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03262 CST11 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CST11 VGNC VGNC:39677
Macaca mulatta CST11 VGNC VGNC:71415
Rattus norvegicus CST11 RGD RGD:620589
Mus musculus CST11 MGD MGI:1925490
Felis catus CST11 VGNC VGNC:61235
Bos taurus CST11 VGNC VGNC:27776