2. Gene
  3. SIRPA - signal regulatory protein alpha Gene

SIRPA - signal regulatory protein alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1

Gene ID: 140885 | Gene type: protein coding

About SIRPA

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,894,167-1,940,592 (from NCBI)

This gene has 4 transcripts (splice variants), 290 orthologues, 4 paralogues and is associated with 60 phenotypes. Ubiquitous expression in brain (RPKM 71.2), appendix (RPKM 27.2) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

SIRPA Products(4)

mRNA Protein Name
NM_001040022.1 NP_001035111.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor
NM_001040023.2 NP_001035112.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor
NM_001330728.1 NP_001317657.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor
NM_080792.3 NP_542970.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

SIRPA Protein Structure

V-set

V-set: Immunoglobulin V-set domain (35 - 144)

C1-set

C1-set: Immunoglobulin C1-set domain (161 - 236)

C1-set

C1-set: Immunoglobulin C1-set domain (262 - 339)

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  • 504 a.a.
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type substrate 1

CD172 antigen-like family member A

Recombinant SIRPA Proteins

Cat. No. Product Name Accession Purity
HY-P7405 SIRP alpha/CD172a Protein, Human (HEK293, His-Myc) P78324 (E31-R370) ≥95%
HY-P7406 SIRP alpha/CD172a Protein, Human (HEK293, Fc) P78324 (E31-R370) ≥95%
HY-P70484 SIRP alpha/CD172a Protein, Human (CAA71403, HEK293, His) CAA71403.1 (E31-R370) ≥95%
HY-P70689 SIRP alpha/CD172a Protein, Human (CAA71403, HEK293, Fc) CAA71403.1 (E31-R370) ≥95%
HY-P72412 SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) P78324 (E31-R370) ≥95%
HY-P74546 SIRP alpha/CD172a Protein, Human (G75A, HEK293, His) P78324 (E31-R370, G75A) ≥95%
HY-P76066 SIRP alpha V2/CD172a Protein, Human (AAH38510, HEK293, His) AAH38510 (M1-R369) ≥95%
HY-P76067 SIRP alpha V2/CD172a Protein, Human (AAH38510, HEK293, Fc) AAH38510 (M1-R369) ≥95%
HY-P76068 SIRP alpha V8/CD172a Protein, Human (AAH38510, HEK293, His) AAH38510 (E31-R369, S44L, S50T, I52T, H54R, V57A) ≥95%
HY-P76069 SIRP alpha V8/CD172a Protein, Human (AAH38510, HEK293, Fc) AAH38510 (E31-R369, S44L, S50T, I52T, H54R, V57A) ≥95%
HY-P77843 SIRP alpha V4/CD172a Protein, Human (HEK293, His-Avi) P78324 (E31-R370, E33G, L44S, T50S, T52I, R54H) ≥95%
HY-P77844 SIRP alpha V4/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) P78324 (E31-R370, E33G, L44S, T50S, T52I, R54H) ≥95%
HY-P77846 SIRP alpha V6/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) P78324 (E31-R370, S105P) ≥95%
HY-P77836 SIRP alpha V2/CD172a Protein, Human (339a.a, HEK293, His) AAH26692.1 (E31-R369) ≥95%
HY-P77837 SIRP alpha V2/CD172a Protein, Human (339a.a, HEK293, Fc) AAH26692.1 (E31-R369) ≥95%
HY-P77840 SIRP alpha V2/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) AAH38510 (E31-R369) ≥95%
HY-P77841 SIRP alpha V3 Protein, Human (H54L, HEK293, His-Avi) AAH38510 (E31-R369, H54L) ≥95%
HY-P77842 SIRP alpha V3 Protein, Human (Biotinylated, H54L, HEK293, His-Avi) AAH38510 (E31-R369, H54L) ≥95%
HY-P77845 SIRP alpha V6/CD172a Protein, Human (HEK293, His-Avi) P78324 (E31-R370, S105P) ≥95%
HY-P77847 SIRP alpha V8/CD172a Protein, Human (S44L, S50T, I52T, H54R, V57A, HEK293, His-Avi) ATD50864.1 (E31-R369, S44L, S50T, I52T, H54R, V57A) ≥95%
HY-P78211 SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, Fc-Avi) P78324 (E31-R370) ≥95%

Related Diseases

Diseases Alias
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Tenosynovial Giant Cell Tumor

Fibrous Histiocytoma Of Tendon Sheath

Giant Cell Tumor Of Tendon Sheath

Giant Cell Tumor Of Tenosynovium

Giant Cell Tumour Of Tendon Sheath

Giant Cell Tumour Of Tenosynovium

Tenosynovial Giant Cell Tumour

Diffuse-Type Gct

Diffuse-Type Giant Cell Tumor

Pigmented Villonodular Synovitis

Tgct

Tsgct
Refractory Plasma Cell Neoplasm
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia
Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12932 SIRPA Human Pre-designed siRNA Set A / Unkown
HY-N12840 Logmalicid B / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SIRPA MGD MGI:108563
Rattus norvegicus SIRPA RGD RGD:3449
Macaca fascicularis SIRPA NCBI
Others SIRPA NCBI