MEI1 - meiotic double-stranded break formation protein 1 Gene

Homo sapiens

Also known as HYDM3; SPATA38

Gene ID: 150365 | Gene type: protein coding

About MEI1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,699,503-41,799,454 (from NCBI)

This gene has 16 transcripts (splice variants), 181 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 5.5), spleen (RPKM 2.0) and 13 other tissues.

Summary

Predicted to be involved in meiosis I. Predicted to act upstream of or within gamete generation; meiotic spindle organization; and meiotic telomere clustering. Implicated in gestational trophoblastic neoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MEI1 Products(1)

mRNA	Protein	Name
NM_152513.4	NP_689726.3	meiosis inhibitor protein 1

Protein Preferred Names

Protein Names

meiosis inhibitor protein 1

meiosis defective 1

Related Diseases

Diseases

Alias

Hydatidiform Mole, Recurrent, 3

HYDM3

Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole	Gestational Trophoblastic Disease
Complete Hydatidiform Mole	Hydm
HYDM1	Chm
Molar Pregnancy	Hydatidiform Mole, Complete
Hydatid Mole	Complete Molar Pregnancy
Mole, Hydatidiform, Recurrent, Type 1	Gestational Trophoblastic Neoplasms
Hydatidiform Mole, Recurrent, 2	Classical Hydatidiform Mole

Trophoblastic Neoplasm

Trophoblastic Tumor

Trophoblastic Neoplasms

Gestational Trophoblastic Neoplasm

Hydatidiform Mole	Molar Pregnancy
Gestational Trophoblastic Neoplasia	Gestational Trophoblastic Tumor
Gtn	Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasms	Hydatidiform Mole, Recurrent, 1
Hydatidiform Mole Benign	Trophoblastic Disease
Trophoblastic Disease Nos	Trophoblastic Disorder
Vesicular Mole Nos	Vesicular Mole
Hydatidiform Mole Nos

Lumbosacral Lipoma

Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa	Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna
SPGF5	Macrocephalic Sperm Head Syndrome
Male Infertility Due To Macrozoospermia	Infertility Associated With Multitailed Spermatozoa And Excessive Dna
Macrozoospermia	Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa
Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid	Large-Headed Multiflagellar Polyploid Spermatozoa
Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa

Cerebrooculofacioskeletal Syndrome 2

COFS2	Cerebro-Oculo-Facio-Skeletal Syndrome 2
Cofs Syndrome

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132870	MEIS-IN-2	Inhibitor	/	Unkown
HY-155526	FY-21	Inhibitor	/	Unkown
HY-160018	BAY-155	Inhibitor	/	Unkown
HY-RS08319	MEI1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08325	MEIS1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MEI1	MGD	MGI:3028590
Bos taurus	MEI1	VGNC	VGNC:31378
Felis catus	MEI1	VGNC	VGNC:63446
Canis familiaris	MEI1	VGNC	VGNC:43149
Macaca mulatta	MEI1	VGNC	VGNC:95361
Rattus norvegicus	MEI1	RGD	RGD:1307210

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