CXADR - CXADR Ig-like cell adhesion molecule Gene

Homo sapiens

Also known as CAR; HCAR; CAR4/6

Gene ID: 1525 | Gene type: protein coding

About CXADR

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:17,513,043-17,636,262 (from NCBI)

This gene has 5 transcripts (splice variants), 218 orthologues and 14 paralogues. Ubiquitous expression in skin (RPKM 12.7), duodenum (RPKM 7.3) and 23 other tissues.

Summary

The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]

CXADR Products(5)

mRNA	Protein	Name
NM_001207063.2	NP_001193992.1	coxsackievirus and adenovirus receptor isoform 2 precursor
NM_001207064.2	NP_001193993.1	coxsackievirus and adenovirus receptor isoform 3 precursor
NM_001207065.2	NP_001193994.1	coxsackievirus and adenovirus receptor isoform 4 precursor
NM_001207066.2	NP_001193995.1	coxsackievirus and adenovirus receptor isoform 5 precursor
NM_001338.5	NP_001329.1	coxsackievirus and adenovirus receptor isoform 1 precursor

CXADR Protein Structure

V-set

Ig_2

0
100
200
300
365 a.a.

Protein Preferred Names

Protein Names

coxsackievirus and adenovirus receptor

46 kD coxsackievirus and adenovirus receptor (CAR) protein

Recombinant CXADR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70049	CXADR Protein, Human (HEK293, His)	P78310/NP_001329.1 (L20-G237)	≥95%

Related Diseases

Diseases

Alias

Pharyngoconjunctival Fever

Pharyngo-Conjunctival Fever	Adenoviral Pharyngoconjunctivitis
Adenovirus Infections, Human

Shipyard Eye

Epidemic Keratoconjunctivitis

Ekc

Hypocalcemia, Autosomal Dominant 1

Autosomal Dominant Hypocalcemia	Autosomal Dominant Hypocalcemia 1
HYPOC1	Hypocalcemia, Autosomal Dominant
Hypercalciuric Hypocalcemia	Hypocalcemia, Autosomal Dominant, With Bartter Syndrome
Familial Hypocalcemia	Hypocalcemia, Familial
Hypoc	Adh
Autosomal Dominant Hypoparathyroidism	Familial Hypercalciuric Hypocalcemia
Ad Hypocalcemia	Autosomal Dominant Hypocalcemia With Bartter Syndrome
Hypoparathyroidism - Autosomal Dominant	Hypocalcemia

Familial Hypocalciuric Hypercalcemia

Familial Benign Hypercalcemia	Fbh
Fbhh	Fhh
Familial Benign Hypocalciuric Hypercalcemia	Hypocalciuric Hypercalcemia, Familial, Type 1

Myocarditis

Myocardial Inflammation

Inflammatory Cardiomyopathy

Hyperparathyroidism, Neonatal Severe

NSHPT	Neonatal Severe Primary Hyperparathyroidism
Nsph	Nhpt
Hyperparathyroidism, Neonatal	Hyperparathyroidism, Neonatal Severe Primary
Neonatal Severe Hyperparathyroidism	Hyperparathyroidism, Severe, Neonatal
Neonatal Hyperparathyroidism

Secondary Hyperparathyroidism

Hyperparathyroidism Secondary	Hyperparathyroidism, Secondary
Secondary Hyperparathyroidism Nec

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Primary Hyperparathyroidism

Familial Primary Hyperparathyroidism	Hyperparathyroidism, Primary
Hyperparathyroidism Primary	Hypocalciuric Hypercalcemia, Familial, Type 1
Familial Benign Hypercalcemia	Familial Hyperparathyroidism
Parathyroid Enlargement

Hypoparathyroidism

Hypoparathyroidism, Idiopathic	Parathyroid, Underactivity Of
Syndrome With Hypoparathyroidism	Deficiency Of Parathyroid Hormone
Parathyroid Gland Insufficiency	Parathyroid Insufficiency
Hypoparathyroidism Due To Impaired Pth - [Parathyroid Hormone] Secretion

Usher Syndrome, Type I

USH1	Usher Syndrome Type 1
Us1	Usher Syndrome, Type 1b
Usher Syndrome Type 1e	Retinitis Pigmentosa And Congenital Deafness
Usher Syndrome, Type Ie	USH1E
Usher Syndrome, Type 1e	Usher Syndrome, Type 1a
Usher Syndrome, Type Ib	Usher Syndrome Type 1b
Usher Syndrome Type Ie	Usher Syndrome Type I
Usher 1	Usher Syndrome, Type 1
Ush1a	Usher Syndrome, Type I, French Variety
Usher Syndrome, Type Ia	Usher Syndrome 1b
USH1B	Usher'S Syndrome Type 1b
Usher Syndrome Type Ib	Ushib

Parathyroid Carcinoma

Parathyroid Cancer	Parathyroid Neoplasms
Malignant Tumor Of Parathyroid Gland	PRTC
Carcinoma Of Parathyroid Gland	Malignant Neoplasm Of Parathyroid Gland
Parathyroid Gland Adenocarcinoma	Parathyroid Gland Cancer
Parathyroid Neoplasm	Parathyroid Gland Carcinoma
Malignant Neoplasm Of The Parathyroid	Neoplasm Of Parathyroid Gland
Parathyroid Gland Neoplasm	Cancer Of The Parathyroid
Cancer Of The Parathyroid Gland	Malignant Neoplasm Of Parathyroid
Malignant Parathyroid Gland Neoplasm	Malignant Parathyroid Gland Tumor
Malignant Parathyroid Neoplasm	Malignant Parathyroid Tumor
Malignant Tumor Of Parathyroid	Parathyroid Adenocarcinoma
Neoplasm Of The Parathyroid Gland	Carcinoma, Parathyroid

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Parathyroid Adenoma

Adenoma Of Parathyroid	Adenoma Of The Parathyroid Gland
Parathyroid Gland Adenoma

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Rhabdomyosarcoma

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Extrinsic Cardiomyopathy

High Grade Glioma

Malignant Glioma	Glial Cell Tumor
Glioma, Malignant	Malignant Neuroglial Tumor
Neuroglial Tumor	Glioma
Malignant Gliomas

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lip
Squamous Cell Carcinoma, Head And Neck, Somatic	Carcinoma Of The Head And Neck
Squamous Cell Carcinomas Of Head And Neck	Scchn
Squamous Cell Carcinoma Of The Hypopharynx	Squamous Cell Carcinoma Of The Oropharynx
Squamous Cell Carcinoma Of Salivary Glands	Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses	Squamous Cell Carcinoma Of The Oral Cavity
Squamous Cell Carcinoma Of The Lip	Carcinoma, Squamous Cell Of Head And Neck
Lip Squamous Cell Carcinoma	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03382	CXADR Human Pre-designed siRNA Set A		/	Unkown
HY-N12840	Logmalicid B		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CXADR	VGNC	VGNC:81299
Bos taurus	CXADR	VGNC	VGNC:53521
Felis catus	CXADR	VGNC	VGNC:84870
Rattus norvegicus	CXADR	RGD	RGD:619794
Canis familiaris	CXADR	VGNC	VGNC:56117
Mus musculus	CXADR	MGD	MGI:1201679
Others	CXADR	NCBI

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