FAAH2 - fatty acid amide hydrolase 2 Gene

Homo sapiens

Also known as AMDD

Gene ID: 158584 | Gene type: protein coding

About FAAH2

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:57,121,591-57,489,196 (from NCBI)

This gene has 3 transcripts (splice variants), 160 orthologues and 2 paralogues. Ubiquitous expression in liver (RPKM 2.5), skin (RPKM 1.5) and 24 other tissues.

Summary

This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded Enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl Amino acids. This Enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

FAAH2 Products(3)

mRNA	Protein	Name
NM_001353840.1	NP_001340769.1	fatty-acid amide hydrolase 2 isoform 2
NM_001353841.1	NP_001340770.1	fatty-acid amide hydrolase 2 isoform 3
NM_174912.4	NP_777572.2	fatty-acid amide hydrolase 2 isoform 1

FAAH2 Protein Structure

Amidase

0
100
200
300
400
500
532 a.a.

Protein Preferred Names

Protein Names

fatty-acid amide hydrolase 2

amidase domain containing

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 28

DEE28	Epileptic Encephalopathy, Early Infantile, 28
Eiee28	Developmental And Epileptic Encephalopathy, 28
Early Infantile Epileptic Encephalopathy 28	Encephalopathy, Epileptic, Early Infantile, Type 28

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04653	FAAH2 Human Pre-designed siRNA Set A		/	Unkown

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