APOBEC3H - apolipoprotein B mRNA editing enzyme catalytic subunit 3H Gene

Homo sapiens

Also known as A3H; ARP10; ARP-10

Gene ID: 164668 | Gene type: protein coding

About APOBEC3H

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,097,244-39,104,067 (from NCBI)

This gene has 7 transcripts (splice variants), 88 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 1.2), colon (RPKM 1.0) and 22 other tissues.

Summary

This gene encodes a member of the apolipoprotein B mRNA-editing Enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 Infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

APOBEC3H Products(4)

mRNA	Protein	Name
NM_001166002.3	NP_001159474.2	DNA dC->dU-editing enzyme APOBEC-3H isoform SV-182
NM_001166003.3	NP_001159475.2	DNA dC->dU-editing enzyme APOBEC-3H isoform SV-200
NM_001166004.3	NP_001159476.2	DNA dC->dU-editing enzyme APOBEC-3H isoform SV-154
NM_181773.5	NP_861438.3	DNA dC->dU-editing enzyme APOBEC-3H isoform SV-183

APOBEC3H Protein Structure

APOBEC_N

0
100
200 a.a.

Protein Preferred Names

Protein Names

DNA dC->dU-editing enzyme APOBEC-3H

APOBEC-related protein 10

Related Diseases

Diseases

Alias

Plantar Wart

Verruca Plantaris	Verrucae On Sole Of Foot
Mosaic Plantar Warts

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Bone Giant Cell Sarcoma

Giant Cell Sarcoma Of The Bone

Giant Cell Tumor Of Bone, Malignant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00841	APOBEC3H Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	APOBEC3H	VGNC	VGNC:108124
Macaca mulatta	APOBEC3H	VGNC	VGNC:69894
Rattus norvegicus	APOBEC3H	RGD	RGD:1307800

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