DCP2 - decapping mRNA 2 Gene

Homo sapiens

Also known as NUDT20

Gene ID: 167227 | Gene type: protein coding

About DCP2

Cytogenetic location: 5q22.2 Genomic coordinates (GRCh38): 5:112,976,798-113,022,195 (from NCBI)

This gene has 9 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in lymph node (RPKM 7.7), placenta (RPKM 6.8) and 24 other tissues.

Summary

The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

DCP2 Products(2)

mRNA	Protein	Name
NM_001242377.2	NP_001229306.1	m7GpppN-mRNA hydrolase isoform 2
NM_152624.6	NP_689837.2	m7GpppN-mRNA hydrolase isoform 1

DCP2 Protein Structure

DCP2

NUDIX

0
100
200
300
420 a.a.

Protein Preferred Names

Protein Names

m7GpppN-mRNA hydrolase

DCP2 decapping enzyme homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141472	7-Methylguanosine 5'-diphosphate sodium		≥97.0%	Unkown
HY-RS03586	DCP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DCP2	VGNC	VGNC:27921
Felis catus	DCP2	VGNC	VGNC:61374
Rattus norvegicus	DCP2	RGD	RGD:1562909
Canis familiaris	DCP2	VGNC	VGNC:39810
Macaca mulatta	DCP2	VGNC	VGNC:71700
Mus musculus	DCP2	MGD	MGI:1917890

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