DACT2 - dishevelled binding antagonist of beta catenin 2 Gene

Homo sapiens

Also known as DPR2; DAPPER2; C6orf116; bA503C24.7

Gene ID: 168002 | Gene type: protein coding

About DACT2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:168,292,830-168,319,777 (from NCBI)

This gene has 4 transcripts (splice variants), 175 orthologues and 2 paralogues. Biased expression in placenta (RPKM 6.6), prostate (RPKM 2.5) and 8 other tissues.

Summary

Predicted to enable several functions, including beta-catenin binding activity; delta-catenin binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including epithelial cell morphogenesis; inner medullary collecting duct development; and negative regulation of nodal signaling pathway. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DACT2 Products(3)

mRNA	Protein	Name
NM_001286350.2	NP_001273279.1	dapper homolog 2 isoform b
NM_001286351.2	NP_001273280.1	dapper homolog 2 isoform c
NM_214462.5	NP_999627.2	dapper homolog 2 isoform a

DACT2 Protein Structure

Dapper

0
200
400
600
774 a.a.

Protein Preferred Names

Protein Names

dapper homolog 2

dapper antagonist of catenin 2

Related Diseases

Diseases

Alias

Extraocular Retinoblastoma

Pediatric Extraocular Retinoblastoma

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03516	DACT2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DACT2	RGD	RGD:1310742
Macaca mulatta	DACT2	VGNC	VGNC:71688
Bos taurus	DACT2	VGNC	VGNC:27868
Mus musculus	DACT2	MGD	MGI:1920347
Canis familiaris	DACT2	VGNC	VGNC:39762

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