2. Gene
  3. DHX36 - DEAH-box helicase 36 Gene

DHX36 - DEAH-box helicase 36 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as G4R1; RHAU; DDX36; MLEL1

Gene ID: 170506 | Gene type: protein coding

About DHX36

Cytogenetic location: 3q25.2 Genomic coordinates (GRCh38): 3:154,272,546-154,324,487 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 203 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 24.2), thyroid (RPKM 15.5) and 25 other tissues.

Summary

This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

DHX36 Products(2)

mRNA Protein Name
NM_001114397.2 NP_001107869.1 ATP-dependent DNA/RNA helicase DHX36 isoform 2
NM_020865.3 NP_065916.2 ATP-dependent DNA/RNA helicase DHX36 isoform 1

DHX36 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (212 - 372)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (517 - 606)

HA2

HA2: Helicase associated domain (HA2) (670 - 759)

OB_NTP_bind

OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (812 - 917)

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  • 1008 a.a.
Protein Preferred Names Protein Names

ATP-dependent DNA/RNA helicase DHX36

ATP-dependent RNA helicase DHX36

Related Diseases

Diseases Alias
Dyskeratosis Congenita, Autosomal Recessive 5

Dyskeratosis Congenita, Autosomal Dominant, 4

DKCB5

Autosomal Dominant Dyskeratosis Congenita 4

DKCA4

Autosomal Recessive Dyskeratosis Congenita 5

Dyskeratosis Congenita, Autosomal Recessive, 5

Dyskeratosis Congenita, Autosomal Dominant 4

Dyskeratosis Congenita, Autosomal Recessive, Type 5
Fanconi Anemia, Complementation Group J

Fanconi Anemia Complementation Group J

FANCJ
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03755 DHX36 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DHX36 VGNC VGNC:28054
Macaca mulatta DHX36 VGNC VGNC:71623
Rattus norvegicus DHX36 RGD RGD:1308767
Mus musculus DHX36 MGD MGI:1919412
Felis catus DHX36 VGNC VGNC:61481
Canis familiaris DHX36 VGNC VGNC:39946