DLX1 - distal-less homeobox 1 Gene

Homo sapiens

Gene ID: 1745 | Gene type: protein coding

About DLX1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:172,085,507-172,089,674 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 9 paralogues. Biased expression in brain (RPKM 2.1), adrenal (RPKM 1.3) and 5 other tissues.

Summary

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

DLX1 Products(2)

mRNA	Protein	Name
NM_001038493.2	NP_001033582.1	homeobox protein DLX-1 isoform 2
NM_178120.5	NP_835221.2	homeobox protein DLX-1 isoform 1

DLX1 Protein Structure

Homeobox

0
100
200
255 a.a.

Protein Preferred Names

Protein Names

homeobox protein DLX-1

distal-less homeo box 1

Related Diseases

Diseases

Alias

Split-Hand/Foot Malformation 5

Split Hand-Foot Malformation 5

SHFM5

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03812	DLX1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DLX1	VGNC	VGNC:28098
Mus musculus	DLX1	MGD	MGI:94901
Rattus norvegicus	DLX1	RGD	RGD:1309593
Felis catus	DLX1	VGNC	VGNC:107522
Macaca mulatta	DLX1	VGNC	VGNC:104521
Canis familiaris	DLX1	VGNC	VGNC:39989