ELF4 - E74 like ETS transcription factor 4 Gene

Homo sapiens

Also known as MEF; ELFR; AIFBL2

Gene ID: 2000 | Gene type: protein coding

About ELF4

Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:130,063,955-130,111,927 (from NCBI)

This gene has 3 transcripts (splice variants), 94 orthologues, 28 paralogues and is associated with 63 phenotypes. Broad expression in bone marrow (RPKM 18.8), placenta (RPKM 12.9) and 21 other tissues.

Summary

The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]

ELF4 Products(2)

mRNA	Protein	Name
NM_001127197.2	NP_001120669.1	ETS-related transcription factor Elf-4
NM_001421.4	NP_001412.1	ETS-related transcription factor Elf-4

ELF4 Protein Structure

Elf-1_N

Ets

0
200
400
600
663 a.a.

Protein Preferred Names

Protein Names

ETS-related transcription factor Elf-4

E74-like factor 4 (ets domain transcription factor)

Related Diseases

Diseases

Alias

Autoinflammatory Syndrome, Familial, X-Linked, Behcet-Like 2

Dex	AIFBL2
Deficiency In Elf4, X-Linked

Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia

IGHD3	Ighd Iii
Fleisher Syndrome	Growth Hormone Deficiency With Hypogammaglobulinemia, X-Linked
Hypogammaglobulinemia And Isolated Growth Hormone Deficiency, X-Linked	Agammaglobulinemia And Isolated Growth Hormone Deficiency, X-Linked
Short Stature Due To Isolated Growth Hormone Deficiency With X-Linked Hypogammaglobulinemia	Growth Hormone Deficiency, Isolated, 3, With Agammaglobulinemia
Agammaglobulinemia And Isolated Growth Hormone Deficiency	Isolated Growth Hormone Deficiency Type 3
X-Linked Hypogammaglobulinemia And Isolated Growth Hormone Deficiency

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150612	(R)-STU104	Inhibitor	/	Unkown
HY-RS04301	ELF4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ELF4	VGNC	VGNC:61808
Mus musculus	ELF4	MGD	MGI:1928377
Rattus norvegicus	ELF4	RGD	RGD:1560743
Canis familiaris	ELF4	VGNC	VGNC:40301
Bos taurus	ELF4	VGNC	VGNC:28429
Macaca mulatta	ELF4	VGNC	VGNC:72208

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