2. Gene
  3. Slc1a2 - solute carrier family 1 (glial high affinity glutamate transporter), member 2 Gene

Slc1a2 - solute carrier family 1 (glial high affinity glutamate transporter), member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as GLT1; Eaat2; GLT-1; MGLT1; 1700091C19Rik; 2900019G14Rik

Gene ID: 20511 | Gene type: protein coding

About Slc1a2

Chromosome 2: 102,489,004-102,621,129 forward strand.GRCm39:CM000995.3

This gene has 12 transcripts (splice variants), 287 orthologues, 6 paralogues and is associated with 10 phenotypes. Biased expression in cortex adult (RPKM 172.), frontal lobe adult (RPKM 137.5) and 2 other tissues.

Summary

Enables cysteine transmembrane transporter activity and high-affinity glutamate transmembrane transporter activity. Involved in several processes, including L-glutamate import across plasma membrane; cellular response to cocaine; and glutathione biosynthetic process. Acts upstream of or within several processes, including L-glutamate transmembrane transport; positive regulation of glucose import; and visual behavior. Located in several cellular components, including astrocyte projection; axolemma; and membrane raft. Is integral component of plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and spinal cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a2 Products(4)

mRNA Protein Name
NM_001361018.1 NP_001347947.1 excitatory amino acid transporter 2 isoform 4
NM_001077515.2 NP_001070983.1 excitatory amino acid transporter 2 isoform 2
NM_001077514.4 NP_001070982.1 excitatory amino acid transporter 2 isoform 1
NM_011393.2 NP_035523.1 excitatory amino acid transporter 2 isoform 3

Slc1a2 Protein Structure

SDF

SDF: pfam00375 (45 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 572 a.a.
Protein Preferred Names Protein Names

excitatory amino acid transporter 2

EAAT2 variant mEAAT2/5UT2

EAAT2 variant mEAAT2/5UT5

glutamate transporter 1c

sodium-dependent glutamatespartate transporter 2

solute carrier family 1, member 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13051 SLC1A2 Human Pre-designed siRNA Set A / Unkown
HY-RS13052 Slc1a2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS13053 Slc1a2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc1a2 NCBI NCBI:6506