2. Gene
  3. ACSL1 - acyl-CoA synthetase long chain family member 1 Gene

ACSL1 - acyl-CoA synthetase long chain family member 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ACS1; LACS; FACL1; FACL2; LACS1; LACS2

Gene ID: 2180 | Gene type: protein coding

About ACSL1

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:184,755,595-184,826,594 (from NCBI)

This gene has 16 transcripts (splice variants), 326 orthologues and 12 paralogues. Biased expression in fat (RPKM 357.3), liver (RPKM 217.4) and 10 other tissues.

Summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

ACSL1 Products(18)

mRNA Protein Name
NM_001286708.2 NP_001273637.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001286710.2 NP_001273639.1 long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001286711.2 NP_001273640.1 long-chain-fatty-acid--CoA ligase 1 isoform c
NM_001381877.1 NP_001368806.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381878.1 NP_001368807.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381879.1 NP_001368808.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381880.1 NP_001368809.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381881.1 NP_001368810.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381882.1 NP_001368811.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381883.1 NP_001368812.1 long-chain-fatty-acid--CoA ligase 1 isoform a
NM_001381884.1 NP_001368813.1 long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001381885.1 NP_001368814.1 long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001381886.1 NP_001368815.1 long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001381887.1 NP_001368816.1 long-chain-fatty-acid--CoA ligase 1 isoform b
NM_001381888.1 NP_001368817.1 long-chain-fatty-acid--CoA ligase 1 isoform e
NM_001381889.1 NP_001368818.1 long-chain-fatty-acid--CoA ligase 1 isoform e
NM_001381890.1 NP_001368819.1 long-chain-fatty-acid--CoA ligase 1 isoform f
NM_001995.5 NP_001986.2 long-chain-fatty-acid--CoA ligase 1 isoform a

ACSL1 Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (116 - 562)

  • 0
  • 200
  • 400
  • 600
  • 698 a.a.
Protein Preferred Names Protein Names

long-chain-fatty-acid--CoA ligase 1

LACS 1

Related Diseases

Diseases Alias
Retinal Dystrophy With Leukodystrophy

RDLKD

Acbd5 Deficiency

Dystrophy, Retinal, With Leukodystrophy
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00200 ACSL1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ACSL1 VGNC VGNC:69564
Bos taurus ACSL1 VGNC VGNC:25564
Canis familiaris ACSL1 VGNC VGNC:37532
Felis catus ACSL1 VGNC VGNC:59534
Mus musculus ACSL1 MGD MGI:102797
Rattus norvegicus ACSL1 RGD RGD:2015