MTIF3 - mitochondrial translational initiation factor 3 Gene

Homo sapiens

Also known as IF3mt

Gene ID: 219402 | Gene type: protein coding

About MTIF3

Cytogenetic location: 13q12.2 Genomic coordinates (GRCh38): 13:27,435,643-27,450,564 (from NCBI)

This gene has 12 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in fat (RPKM 26.6), testis (RPKM 20.2) and 25 other tissues.

Summary

This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Oct 2009]

MTIF3 Products(4)

mRNA	Protein	Name
NM_001166261.2	NP_001159733.1	translation initiation factor IF-3, mitochondrial
NM_001166262.2	NP_001159734.1	translation initiation factor IF-3, mitochondrial
NM_001166263.2	NP_001159735.1	translation initiation factor IF-3, mitochondrial
NM_152912.5	NP_690876.3	translation initiation factor IF-3, mitochondrial

MTIF3 Protein Structure

IF3_N

IF3_C

0
100
200
278 a.a.

Protein Preferred Names

Protein Names

translation initiation factor IF-3, mitochondrial

IF-3(Mt)

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 39

COXPD39	Combined Oxidative Phosphorylation Defect Type 39
Gfm2-Related Combined Oxidative Phosphorylation Defect

Hallucinogen Abuse

Combined Oxidative Phosphorylation Deficiency 3

Fatal Mitochondrial Disease Due To Combined Oxidative Phosphorylation Defect Type 3	COXPD3
Encephalomyopathy, Respiratory Failure, And Lactic Acidosis	Concentric Cardiomyopathy, Hypotonia, And Lactic Acidosis
Fatal Mitochondrial Disease Due To Coxpd3	Concentric Cardiomyopathy Hypotonia And Lactic Acidosis
Encephalomyopathy Respiratory Failure And Lactic Acidosis	Encephalomyopathy With Respiratory Failure And Lactic Acidosis
Combined Oxidative Phosphorylation Deficiency, Type 3

Combined Oxidative Phosphorylation Deficiency 1

Hepatoencephalopathy Due To Combined Oxidative Phosphorylation Defect Type 1	COXPD1
Early Fatal Progressive Hepatoencephalopathy	Hepatoencephalopathy Due To Coxpd1
Combined Oxidative Phosphorylation Deficiency, Type 1	Hepatoencephalopathy, Early Fatal Progressive
Hepatoencephalopathy Early Fatal Progressive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08782	MTIF3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MTIF3	RGD	RGD:1592673
Macaca mulatta	MTIF3	VGNC	VGNC:75040
Bos taurus	MTIF3	VGNC	VGNC:31734
Mus musculus	MTIF3	MGD	MGI:1923616
Canis familiaris	MTIF3	VGNC	VGNC:43476
Felis catus	MTIF3	VGNC	VGNC:63651

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