HNRNPA3 - heterogeneous nuclear ribonucleoprotein A3 Gene

Homo sapiens

Also known as FBRNP; HNRPA3; D10S102; 2610510D13Rik

Gene ID: 220988 | Gene type: protein coding

About HNRNPA3

Cytogenetic location: 2q31.2 Genomic coordinates (GRCh38): 2:177,212,794-177,223,959 (from NCBI)

This gene has 19 transcripts (splice variants), 129 orthologues and 36 paralogues. Ubiquitous expression in appendix (RPKM 56.8), lymph node (RPKM 56.0) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

HNRNPA3 Products(7)

mRNA	Protein	Name
NM_001330247.2	NP_001317176.1	heterogeneous nuclear ribonucleoprotein A3 isoform b
NM_001330248.2	NP_001317177.1	heterogeneous nuclear ribonucleoprotein A3 isoform b
NM_001330249.2	NP_001317178.1	heterogeneous nuclear ribonucleoprotein A3 isoform a
NM_001330250.2	NP_001317179.1	heterogeneous nuclear ribonucleoprotein A3 isoform c
NM_001330251.2	NP_001317180.1	heterogeneous nuclear ribonucleoprotein A3 isoform c
NM_001395170.1	NP_001382099.1	heterogeneous nuclear ribonucleoprotein A3 isoform d
NM_194247.4	NP_919223.1	heterogeneous nuclear ribonucleoprotein A3 isoform a

HNRNPA3 Protein Structure

RRM_1

0
100
200
300
378 a.a.

Protein Preferred Names

Protein Names

heterogeneous nuclear ribonucleoprotein A3

epididymis secretory sperm binding protein

Related Diseases

Diseases

Alias

Multisystem Proteinopathy

X-Linked Hereditary Ataxia

Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome	Fragile X Tremor/Ataxia Syndrome
Fxtas

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1	Frontotemporal Dementia And/Or Motor Neuron Disease
Ftdmnd	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia
Alsftd	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1	Frontotemporal Dementia With Motor Neuron Disease
Ftdals	Ftd-Als
Ftd-Mnd	Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1	Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1
Frontotemporal Lobar Degeneration	Grn-Related Frontotemporal Dementia

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06263	HNRNPA3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HNRNPA3	VGNC	VGNC:99367
Mus musculus	HNRNPA3	MGD	MGI:1917171
Canis familiaris	HNRNPA3	VGNC	VGNC:41728
Felis catus	HNRNPA3	VGNC	VGNC:80231
Rattus norvegicus	HNRNPA3	RGD	RGD:727807
Bos taurus	HNRNPA3	VGNC	VGNC:50100

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