FER - FER tyrosine kinase Gene

Homo sapiens

Also known as TYK3; PPP1R74; p94-Fer

Gene ID: 2241 | Gene type: protein coding

About FER

Cytogenetic location: 5q21.3 Genomic coordinates (GRCh38): 5:108,747,897-109,196,841 (from NCBI)

This gene has 9 transcripts (splice variants), 222 orthologues and 32 paralogues. Ubiquitous expression in thyroid (RPKM 2.8), testis (RPKM 2.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane Receptor Tyrosine Kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the Cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015]

FER Products(4)

mRNA	Protein	Name
NM_001308028.2	NP_001294957.1	tyrosine-protein kinase Fer isoform b
NM_001308031.2	NP_001294960.1	tyrosine-protein kinase Fer isoform c
NM_001308038.2	NP_001294967.1	tyrosine-protein kinase Fer isoform d
NM_005246.4	NP_005237.2	tyrosine-protein kinase Fer isoform a

FER Protein Structure

FCH

SH2

Pkinase_Tyr

0
200
400
600
822 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase Fer

feline encephalitis virus-related kinase FER

Related Diseases

Diseases

Alias

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Trichothiodystrophy 5, Nonphotosensitive

TTD5	Nonphotosensitive Trichothiodystrophy 5
Trichothiodystrophy 5, Non-Photosensitive

Ceroid Lipofuscinosis, Neuronal, 6a

Neuronal Ceroid Lipofuscinosis 6	CLN6
Vlincl	Cln6 Disease
Ceroid Lipofuscinosis, Neuronal, 6	Late-Infantile Neuronal Ceroid Lipofuscinosis
CLN6A	Neuronal Ceroid Lipofuscinosis, Late Infantile, Variant
Neuronal Ceroid Lipofuscinosis 6a	Neuronal Ceroid Lipofuscinosis 6 Variable Age Of Onset
Cln6 Disease, Adult Kufs Type A	Cln6 Disease, Late Infantile
Neuronal Ceroid Lipofuscinosis, Gypsy/Indian Early Juvenile Variant	Ceroid Lipofuscinosis Neuronal 6
Cln6-Related Neuronal Ceroid Lipofuscinosis	Late Infantile Neuronal Ceroid Lipofuscinosis
Jansky-Bielschowsky Disease	Lincl
Late Infantile Ncl	Neuronal Ceroid Lipofuscinosis 6 With Variable Age At Onset
Variant Late-Onset Infantile Neuronal Ceroid Lipofuscinosis	Ceroid Lipofuscinosis, Neuronal, Late Infantile, Variant
Lipofuscinosis, Ceroid, Neuronal, Type 6	Ceroid Lipofuscinosis, Neuronal, 5

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-122844	Ifebemtinib	Inhibitor	99.86%	Phase 2

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100579	Ferrostatin-1	Inhibitor	99.96%	Unkown
HY-123919	TL13-112	Inhibitor	98.15%	Unkown
HY-112097	E260	Inhibitor	99.05%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-128576	DS21360717	Inhibitor	99.93%	Unkown
HY-116087	SRS11-92	Inhibitor	99.92%	Unkown
HY-122582	TL13-12	Inhibitor	98.06%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-136194	TL13-22	Inhibitor	/	Unkown
HY-136195	TL13-110	Inhibitor	/	Unkown
HY-RS04862	FER Human Pre-designed siRNA Set A		/	Unkown
HY-RS04863	FER1L6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source
Canis familiaris	FER	NCBI
Felis catus	FER	NCBI
Macaca fascicularis	FER	NCBI
Canis lupus familiaris	FER	NCBI
Mus musculus	FER	NCBI
Susscrofa domestica	FER	NCBI
Rattus norvegicus	FER	NCBI
Macaca mulatta	FER	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.