FHL3 - four and a half LIM domains 3 Gene

Homo sapiens

Also known as SLIM2

Gene ID: 2275 | Gene type: protein coding

About FHL3

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:37,996,770-38,005,514 (from NCBI)

This gene has 5 transcripts (splice variants), 285 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 21.3), endometrium (RPKM 16.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the Cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

FHL3 Products(2)

mRNA	Protein	Name
NM_001243878.2	NP_001230807.1	four and a half LIM domains protein 3 isoform 2
NM_004468.5	NP_004459.2	four and a half LIM domains protein 3 isoform 1

FHL3 Protein Structure

LIM

0
100
200
280 a.a.

Protein Preferred Names

Protein Names

four and a half LIM domains protein 3

FHL-3

Related Diseases

Diseases

Alias

Holoprosencephaly 9

Pituitary Anomalies With Holoprosencephaly-Like Features	HPE9
Holoprosencephaly With Microphthalmia And First Branchial Arch Anomalies	Holoprosencephaly-9
Holoprosencephaly, Type 9

Glycogen Storage Disease Vii

Glycogen Storage Disease Type Vii	Muscle Phosphofructokinase Deficiency
Tarui Disease	GSD7
Pfkm Deficiency	Gsd Vii
Glycogen Storage Disease, Type Vii	Glycogen Storage Disease Type 7
Phosphofructokinase Deficiency	Glycogenosis Type Vii
Phosphofructokinase Myopathy	Glycogenosis 7
Glycogen Storage Disease Due To Muscle Phosphofructokinase Deficiency	Gsd Due To Muscle Phosphofructokinase Deficiency
Gsd Type 7	Gsd Type Vii
Glycogenosis Due To Muscle Phosphofructokinase Deficiency	Glycogenosis Type 7
Glycogen Storage Disease 7	Gsd-Vii
Storage Disease, Glycogen, Type Vii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04936	FHL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FHL3	MGD	MGI:1341092
Felis catus	FHL3	VGNC	VGNC:62266
Macaca mulatta	FHL3	VGNC	VGNC:72662
Bos taurus	FHL3	VGNC	VGNC:29001
Canis familiaris	FHL3	VGNC	VGNC:40873
Rattus norvegicus	FHL3	RGD	RGD:1307180
Others	FHL3	NCBI

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