DLGAP4 - DLG associated protein 4 Gene

Homo sapiens

Also known as DAP4; DLP4; DAP-4; SAPAP4; SAPAP-4

Gene ID: 22839 | Gene type: protein coding

About DLGAP4

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,306,339-36,528,633 (from NCBI)

This gene has 15 transcripts (splice variants), 336 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 12.5), endometrium (RPKM 11.0) and 25 other tissues.

Summary

The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DLGAP4 Products(14)

mRNA	Protein	Name
NM_001042486.4	NP_001035951.1	disks large-associated protein 4 isoform c
NM_001365621.2	NP_001352550.1	disks large-associated protein 4 isoform d
NM_001388257.1	NP_001375186.1	disks large-associated protein 4 isoform c
NM_001388260.1	NP_001375189.1	disks large-associated protein 4 isoform c
NM_001388262.1	NP_001375191.1	disks large-associated protein 4 isoform c
NM_001388265.1	NP_001375194.1	disks large-associated protein 4 isoform c
NM_001388268.1	NP_001375197.1	disks large-associated protein 4 isoform c
NM_001388271.1	NP_001375200.1	disks large-associated protein 4 isoform c
NM_001388274.1	NP_001375203.1	disks large-associated protein 4 isoform c
NM_001388275.1	NP_001375204.1	disks large-associated protein 4 isoform c
NM_001388277.1	NP_001375206.1	disks large-associated protein 4 isoform e
NM_001388278.1	NP_001375207.1	disks large-associated protein 4 isoform f
NM_014902.6	NP_055717.2	disks large-associated protein 4 isoform a
NM_183006.4	NP_892118.1	disks large-associated protein 4 isoform b

DLGAP4 Protein Structure

GKAP

0
200
400
600
800
992 a.a.

Protein Preferred Names

Protein Names

disks large-associated protein 4

PSD-95/SAP90-binding protein 4

Related Diseases

Diseases

Alias

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03804	DLGAP4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DLGAP4	VGNC	VGNC:84728
Felis catus	DLGAP4	VGNC	VGNC:61516
Mus musculus	DLGAP4	MGD	MGI:2138865
Canis familiaris	DLGAP4	VGNC	VGNC:39982
Bos taurus	DLGAP4	VGNC	VGNC:28090
Rattus norvegicus	DLGAP4	RGD	RGD:708350

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