PLCL2 - phospholipase C like 2 Gene

Homo sapiens

Also known as PLCE2

Gene ID: 23228 | Gene type: protein coding

About PLCL2

Cytogenetic location: 3p24.3 Genomic coordinates (GRCh38): 3:16,884,955-17,090,606 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 226 orthologues and 14 paralogues. Ubiquitous expression in ovary (RPKM 4.0), lymph node (RPKM 3.4) and 23 other tissues.

Summary

Enables GABA Receptor binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within several processes, including B cell activation; gamma-aminobutyric acid signaling pathway; and negative regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PLCL2 Products(2)

mRNA	Protein	Name
NM_001144382.2	NP_001137854.1	inactive phospholipase C-like protein 2 isoform 1
NM_015184.5	NP_055999.2	inactive phospholipase C-like protein 2 isoform 2

PLCL2 Protein Structure

EF-hand_like

PI-PLC-X

PI-PLC-Y

0
200
400
600
800
1001 a.a.

Protein Preferred Names

Protein Names

inactive phospholipase C-like protein 2

PLC-L(2)

Related Diseases

Diseases

Alias

Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type

Spondyloepimetaphyseal Dysplasia-Short Limb-Abnormal Calcification Syndrome	Smed-Sl
Smed-Sl/Ac	Smed Short Limb-Abnormal Calcification Type
Smed Short Limb-Hand Type	Spondylometaepiphyseal Dysplasia Short Limb-Hand Type
Smed, Type Ii	Smed Type 2
Spondylometaepiphyseal Dysplasia Short Limb-Abnormal Calcification Type	Smed, Short Limb-Hand Type
Spondylometaepiphyseal Dysplasia, Short Limb-Abnormal Calcification Type	Smed, Short Limb-Abnormal Calcification Type
Spondyloepimetaphyseal Dysplasia - Short Limb - Abnormal Calcification	Spondyloepimetaphyseal Dysplasia, Short Limb-Hand Type
SEMD-SL	Smed Type Ii
Dysplasia, Spondylometaepiphyseal, Short Limb-Hand Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10665	PLCL2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLCL2	RGD	RGD:1305941
Mus musculus	PLCL2	MGD	MGI:1352756
Felis catus	PLCL2	VGNC	VGNC:68899
Canis familiaris	PLCL2	VGNC	VGNC:44655
Bos taurus	PLCL2	VGNC	VGNC:32992
Macaca mulatta	PLCL2	VGNC	VGNC:76168

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