2. Gene
  3. SUN1 - Sad1 and UNC84 domain containing 1 Gene

SUN1 - Sad1 and UNC84 domain containing 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UNC84A

Gene ID: 23353 | Gene type: protein coding

About SUN1

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:815,557-874,934 (from NCBI)

This gene has 35 transcripts (splice variants), 264 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 45.0), skin (RPKM 41.1) and 25 other tissues.

Summary

This gene is a member of the unc-84 homolog family and encodes a nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2019]

SUN1 Products(72)

mRNA Protein Name
NM_001130965.3 NP_001124437.1 SUN domain-containing protein 1 isoform a
NM_001171944.2 NP_001165415.1 SUN domain-containing protein 1 isoform c
NM_001171945.2 NP_001165416.1 SUN domain-containing protein 1 isoform d
NM_001171946.2 NP_001165417.1 SUN domain-containing protein 1 isoform e
NM_001367633.1 NP_001354562.1 SUN domain-containing protein 1 isoform a
NM_001367634.1 NP_001354563.1 SUN domain-containing protein 1 isoform a
NM_001367635.1 NP_001354564.1 SUN domain-containing protein 1 isoform f
NM_001367636.1 NP_001354565.1 SUN domain-containing protein 1 isoform g
NM_001367637.1 NP_001354566.1 SUN domain-containing protein 1 isoform h
NM_001367638.1 NP_001354567.1 SUN domain-containing protein 1 isoform i
NM_001367639.1 NP_001354568.1 SUN domain-containing protein 1 isoform j
NM_001367640.1 NP_001354569.1 SUN domain-containing protein 1 isoform k
NM_001367641.1 NP_001354570.1 SUN domain-containing protein 1 isoform l
NM_001367642.1 NP_001354571.1 SUN domain-containing protein 1 isoform m
NM_001367643.1 NP_001354572.1 SUN domain-containing protein 1 isoform n
NM_001367644.1 NP_001354573.1 SUN domain-containing protein 1 isoform o
NM_001367645.1 NP_001354574.1 SUN domain-containing protein 1 isoform p
NM_001367646.1 NP_001354575.1 SUN domain-containing protein 1 isoform q
NM_001367647.1 NP_001354576.1 SUN domain-containing protein 1 isoform r
NM_001367648.1 NP_001354577.1 SUN domain-containing protein 1 isoform s
NM_001367649.1 NP_001354578.1 SUN domain-containing protein 1 isoform t
NM_001367651.1 NP_001354580.1 SUN domain-containing protein 1 isoform u
NM_001367653.1 NP_001354582.1 SUN domain-containing protein 1 isoform v
NM_001367655.1 NP_001354584.1 SUN domain-containing protein 1 isoform w
NM_001367658.1 NP_001354587.1 SUN domain-containing protein 1 isoform x
NM_001367660.1 NP_001354589.1 SUN domain-containing protein 1 isoform y
NM_001367662.1 NP_001354591.1 SUN domain-containing protein 1 isoform z
NM_001367664.1 NP_001354593.1 SUN domain-containing protein 1 isoform aa
NM_001367665.1 NP_001354594.1 SUN domain-containing protein 1 isoform bb
NM_001367666.1 NP_001354595.1 SUN domain-containing protein 1 isoform cc
NM_001367667.1 NP_001354596.1 SUN domain-containing protein 1 isoform dd
NM_001367668.1 NP_001354597.1 SUN domain-containing protein 1 isoform ee
NM_001367669.1 NP_001354598.1 SUN domain-containing protein 1 isoform ff
NM_001367670.1 NP_001354599.1 SUN domain-containing protein 1 isoform gg
NM_001367671.1 NP_001354600.1 SUN domain-containing protein 1 isoform hh
NM_001367672.1 NP_001354601.1 SUN domain-containing protein 1 isoform ii
NM_001367673.1 NP_001354602.1 SUN domain-containing protein 1 isoform jj
NM_001367674.1 NP_001354603.1 SUN domain-containing protein 1 isoform kk
NM_001367675.1 NP_001354604.1 SUN domain-containing protein 1 isoform ll
NM_001367676.1 NP_001354605.1 SUN domain-containing protein 1 isoform mm
NM_001367677.1 NP_001354606.1 SUN domain-containing protein 1 isoform nn
NM_001367678.1 NP_001354607.1 SUN domain-containing protein 1 isoform oo
NM_001367679.1 NP_001354608.1 SUN domain-containing protein 1 isoform pp
NM_001367680.1 NP_001354609.1 SUN domain-containing protein 1 isoform qq
NM_001367681.1 NP_001354610.1 SUN domain-containing protein 1 isoform rr
NM_001367682.1 NP_001354611.1 SUN domain-containing protein 1 isoform ss
NM_001367683.1 NP_001354612.1 SUN domain-containing protein 1 isoform tt
NM_001367684.1 NP_001354613.1 SUN domain-containing protein 1 isoform uu
NM_001367685.1 NP_001354614.1 SUN domain-containing protein 1 isoform vv
NM_001367686.1 NP_001354615.1 SUN domain-containing protein 1 isoform ww
NM_001367687.1 NP_001354616.1 SUN domain-containing protein 1 isoform xx
NM_001367688.1 NP_001354617.1 SUN domain-containing protein 1 isoform yy
NM_001367689.1 NP_001354618.1 SUN domain-containing protein 1 isoform zz
NM_001367690.1 NP_001354619.1 SUN domain-containing protein 1 isoform aaa
NM_001367691.1 NP_001354620.1 SUN domain-containing protein 1 isoform bbb
NM_001367692.1 NP_001354621.1 SUN domain-containing protein 1 isoform ccc
NM_001367693.1 NP_001354622.1 SUN domain-containing protein 1 isoform ddd
NM_001367694.1 NP_001354623.1 SUN domain-containing protein 1 isoform eee
NM_001367695.1 NP_001354624.1 SUN domain-containing protein 1 isoform fff
NM_001367696.1 NP_001354625.1 SUN domain-containing protein 1 isoform ggg
NM_001367697.1 NP_001354626.1 SUN domain-containing protein 1 isoform hhh
NM_001367698.1 NP_001354627.1 SUN domain-containing protein 1 isoform iii
NM_001367699.1 NP_001354628.1 SUN domain-containing protein 1 isoform jjj
NM_001367700.1 NP_001354629.1 SUN domain-containing protein 1 isoform kkk
NM_001367701.1 NP_001354630.1 SUN domain-containing protein 1 isoform lll
NM_001367702.1 NP_001354631.1 SUN domain-containing protein 1 isoform mmm
NM_001367703.1 NP_001354632.1 SUN domain-containing protein 1 isoform nnn
NM_001367704.1 NP_001354633.1 SUN domain-containing protein 1 isoform ooo
NM_001367705.1 NP_001354634.1 SUN domain-containing protein 1 isoform ppp
NM_001367706.1 NP_001354635.1 SUN domain-containing protein 1 isoform qqq
NM_001367708.1 NP_001354637.1 SUN domain-containing protein 1 isoform sss
NM_025154.6 NP_079430.3 SUN domain-containing protein 1 isoform b

SUN1 Protein Structure

MRP

MRP: Mitochondrial RNA binding protein MRP (61 - 292)

Sad1_UNC

Sad1_UNC: Sad1 / UNC-like C-terminal (649 - 782)

  • 0
  • 200
  • 400
  • 600
  • 785 a.a.
Protein Preferred Names Protein Names

SUN domain-containing protein 1

Sad1 unc-84 domain protein 1

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 76

DFNB76

Autosomal Recessive Nonsyndromic Deafness 76

Autosomal Recessive Deafness 76

Deafness, Autosomal Recessive, 76

Deafness, Autosomal Recessive, Type 76
Hyperalphalipoproteinemia 1

Hyperalphalipoproteinemia

HALP1

Cetp Deficiency

Cholesterol-Ester Transfer Protein Deficiency

Familial Hyperalphalipoproteinemia

Cholesteryl Ester Transfer Protein Deficiency

Cept Deficiency

Cholesterol Ester Transfer Protein Deficiency
Emery-Dreifuss Muscular Dystrophy 5, Autosomal Dominant

EDMD5

Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 5

Emd5

Dystrophy, Muscular, Emery-Dreifuss, Type 5, Autosomal Dominant
Deafness, Autosomal Recessive 40

DFNB40

Autosomal Recessive Nonsyndromic Deafness 40

Autosomal Recessive Deafness 40
Deafness, Autosomal Recessive 55

DFNB55

Autosomal Recessive Nonsyndromic Deafness 55

Autosomal Recessive Deafness 55
Emery-Dreifuss Muscular Dystrophy 1, X-Linked

EDMD1

Emd1

Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures

X-Linked Emery-Dreifuss Muscular Dystrophy 1

Humeroperoneal Neuromuscular Disease

X-Linked Emery-Dreifuss Muscular Dystrophy

Scapuloperoneal Syndrome, X-Linked, Formerly

Humeroperoneal Neuromuscular Disease, Formerly

Scapuloperoneal Syndrome, X-Linked

Muscular Dystrophy Tardive Dreifuss-Emery Type With Contractures

Scapuloperoneal Syndrome X-Linked

X-Edmd

Dystrophy, Muscular, Emery-Dreifuss, Type 1, X-Linked
Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant

EDMD2

Autosomal Dominant Emery-Dreifuss Muscular Dystrophy

Emd2

Emery-Dreifuss Muscular Dystrophy, Autosomal Dominant

Scapuloilioperoneal Atrophy With Cardiopathy

Muscular Dystrophy With Early Contractures And Cardiomyopathy, Autosomal Dominant

Hauptmann-Thannhauser Muscular Dystrophy

Cardiomyopathy, Dilated, With Quadriceps Myopathy

Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 2

Muscular Dystrophy, Limb-Girdle, Type 1b

Muscular Dystrophy, Limb-Girdle, Type 1b, Formerly

Lgmd1b, Formerly

Muscular Dystrophy, Proximal, Type 1b, Formerly

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1b

Lgmd1b

Limb-Girdle Muscular Dystrophy 1b

Muscular Dystrophy, Proximal, Type 1b

Muscular Dystrophy With Early Contractures And Cardiomyopathy Autosomal Dominant
Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

EDMD3

Autosomal Recessive Emery-Dreifuss Muscular Dystrophy 3

Autosomal Recessive Emery-Dreifuss Muscular Dystrophy

Emery-Dreifuss Muscular Dystrophy Atypical Autosomal Recessive

Dystrophy, Muscular, Emery-Dreifuss, Type 3, Autosomal Recessive

Emery-Dreifuss Muscular Dystrophy 3
Emery-Dreifuss Muscular Dystrophy 7, Autosomal Dominant

EDMD7

Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 7

Emery-Dreifuss Muscular Dystrophy 7, Ad

Emd7

Dystrophy, Muscular, Emery-Dreifuss, Type 7, Autosomal Dominant
Charcot-Marie-Tooth Disease, Axonal, Type 2b1

Charcot-Marie-Tooth Disease Type 2b1

Charcot-Marie-Tooth Disease, Type 2b1

CMT2B1

Autosomal Recessive Axonal Cmt4c1

Autosomal Recessive Charcot-Marie-Tooth Disease Type 2b1

Charcot-Marie-Tooth Disease Neuronal Type 2b1

Charcot-Marie-Tooth Neuropathy Type 2b1

Charcot-Marie-Tooth Disease, Neuronal, Type 2b1

Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2b1

Charcot-Marie-Tooth Neuropathy, Type 2b1

Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2b1

Ar-Cmt2b1

Charcot-Marie-Tooth Disease 2b1

Charcot-Marie-Tooth Disease Axonal Autosomal Recessive B1

Charcot-Marie-Tooth Disease Axonal Type 2b1
Emery-Dreifuss Muscular Dystrophy 4, Autosomal Dominant

EDMD4

Emery-Dreifuss Muscular Dystrophy 4 With Variable Features

Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 4

Emd4

Dystrophy, Muscular, Emery-Dreifuss, Type 4, Autosomal Dominant

Emery-Dreifuss Muscular Dystrophy 4
Emery-Dreifuss Muscular Dystrophy

Edmd

Emery-Dreifuss Syndrome

Muscular Dystrophy, Emery-Dreifuss

Humeroperoneal Neuromuscular Disease

Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures

Scapuloperoneal Syndrome, X-Linked

Benign Scapuloperoneal Muscular Dystrophy With Early Contractures

Muscular Dystrophy, Emery-Dreifuss Type

Muscular Dystrophy Emery-Dreifuss

Dystrophy, Muscular, Emery-Dreifuss

Emd - [Emery-Dreifuss Muscular Dystrophy]
Muscular Dystrophy, Congenital, Lmna-Related

Congenital Muscular Dystrophy

Congenital Muscular Dystrophy Due To Lmna Mutation

MDCL

L-Cmd

Lmna-Related Congenital Muscular Dystrophy

Muscular Dystrophy, Congenital

Congenital Muscular Dystrophy Lmna-Related

Lmna-Related Cmd

Cmd

Mdc

Muscular Dystrophy Congenital Lmna-Related

Dystrophy, Muscular, Congenital, Lmna-Related

Dystrophy, Muscular, Congenital

Hereditary Muscular Dystrophy

Congenital Hereditary Muscular Dystrophy

Congenital Progressive Muscular Dystrophy

Hereditary Progressive Muscular Dystrophy
Greenberg Dysplasia

Hem Dysplasia

Greenberg Skeletal Dysplasia

Hem Skeletal Dysplasia

GRBGD

Hydrops-Ectopic Calcification-Moth-Eaten Skeletal Dysplasia

Moth-Eaten Skeletal Dysplasia

Chondrodystrophy, Hydropic And Prenatally Lethal Type

Hydrops-Ectopic Calcification-Motheaten Syndrome

Skeletal Dysplasia, Greenberg Type

Autosomal Recessive Lethal Chondrodystrophy With Congenital Hydrops

Hydrops, Ectopic Calcification, Moth-Eaten Skeletal Dysplasia

Hem

Hem/Greenberg Dysplasia

Hydrops - Ectopic Calcification - Moth-Eaten Skeletal Dysplasia
Myopathy, X-Linked, With Postural Muscle Atrophy

Emery-Dreifuss Muscular Dystrophy 6, X-Linked

XMPMA

X-Linked Myopathy With Postural Muscle Atrophy

X-Linked Emery-Dreifuss Muscular Dystrophy 6

EDMD6

Emd6
Pelger-Huet Anomaly

PHA

Pelger-Huët Anomaly

Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities

Pelger Huet Anomaly

Pelger-Huet Nuclear Anomaly
Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy
Spinocerebellar Ataxia, Autosomal Recessive 8

Arca1

Autosomal Recessive Cerebellar Ataxia Type 1

SCAR8

Autosomal Recessive Spinocerebellar Ataxia 8

Autosomal Recessive Ataxia, Beauce Type

Recessive Ataxia Of Beauce

Syne1-Related Autosomal Recessive Cerebellar Ataxia

Ataxia, Recessive, Of Beauce

Cerebellar Ataxia, Autosomal Recessive, Type 1

Spinocerebellar Ataxia Autosomal Recessive 8

Autosomal Recessive Ataxia Beauce Type

Spinocerebellar Ataxia, Autosomal Recessive, 8

Ataxia Recessive Of Beauce

Ataxia, Spinocerebellar, Autosomal Recessive, Type 8
Cardiomyopathy, Dilated, 1h

Dilated Cardiomyopathy 1h

Dilated Cardiomyopathy With Conduction Defect

CMD1H

Cardiomyopathy, Dilated, With Conduction Defect
Cardiomyopathy, Dilated, 1a

Dilated Cardiomyopathy 1a

Cdcd1

CMD1A

Cardiomyopathy, Familial Idiopathic

Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation

Cardiomyopathy, Dilated, With Conduction Defect 1

Cardiomyopathy, Idiopathic Dilated

Cardiomyopathy, Congestive

Dilated Cardiomyopathy With Conduction Defect 1

Cardiomyopathy Dilated With Conduction Defect Type 1

Cardiomyopathy, Dilated 1a

Cardiomyopathy Dilated With Conduction Defect 1

Cardiomyopathy, Dilated, Type 1a
Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14029 SUN1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SUN1 VGNC VGNC:106960
Mus musculus SUN1 MGD MGI:1924303
Macaca mulatta SUN1 VGNC VGNC:78161
Canis familiaris SUN1 VGNC VGNC:46984
Rattus norvegicus SUN1 RGD RGD:1359142
Felis catus SUN1 VGNC VGNC:65841