1. Gene
  2. GRIP1 - glutamate receptor interacting protein 1 Gene

GRIP1 - glutamate receptor interacting protein 1 Gene

Homo sapiens

Also known as GRIP; FRASRS3

Gene ID: 23426 | Gene type: protein coding

About GRIP1

Cytogenetic location: 12q14.3 Genomic coordinates (GRCh38): 12:66,347,431-67,069,338 (from NCBI)

This gene has 20 transcripts (splice variants), 207 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in placenta (RPKM 1.6), skin (RPKM 1.5) and 23 other tissues.

Summary

This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]

GRIP1 Products(11)

mRNA Protein Name
NM_001178074.2 NP_001171545.1 glutamate receptor-interacting protein 1 isoform 2
NM_001366722.1 NP_001353651.1 glutamate receptor-interacting protein 1 isoform 3
NM_001366723.1 NP_001353652.1 glutamate receptor-interacting protein 1 isoform 4
NM_001366724.1 NP_001353653.1 glutamate receptor-interacting protein 1 isoform 5
NM_001379345.1 NP_001366274.1 glutamate receptor-interacting protein 1 isoform 6
NM_001379346.1 NP_001366275.1 glutamate receptor-interacting protein 1 isoform 7
NM_001379347.1 NP_001366276.1 glutamate receptor-interacting protein 1 isoform 8
NM_001379348.1 NP_001366277.1 glutamate receptor-interacting protein 1 isoform 9
NM_001379349.1 NP_001366278.1 glutamate receptor-interacting protein 1 isoform 10
NM_001379351.1 NP_001366280.1 glutamate receptor-interacting protein 1 isoform 11
NM_021150.4 NP_066973.2 glutamate receptor-interacting protein 1 isoform 1

GRIP1 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (54 - 133)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (152 - 235)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (259 - 333)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (477 - 558)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (575 - 655)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (674 - 751)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1006 - 1082)

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  • 1128 a.a.
Protein Preferred Names Protein Names

glutamate receptor-interacting protein 1

Related Diseases

Diseases Alias
Fraser Syndrome 3

FRASRS3

Fraser Syndrome 1

Fraser Syndrome

Cryptophthalmos With Other Malformations

Cryptophthalmos Syndrome

FRASRS1

Cryptophthalmos-Syndactyly Syndrome

Fraser-Francois Syndrome

Cyclopism

Meyer-Schwickerath'S Syndrome

Ulrich-Feichtiger Syndrome

Cryptophthalmos Syndactyly Syndrome

Fraser'S Syndrome

Meyer-Schwickerath Syndrome

Ullrich-Feichtiger Syndrome

Cryptophthalmos
Renal Hypodysplasia/Aplasia 1

Renal Agenesis

Renal Adysplasia

Renal Aplasia

RHDA1

Hereditary Renal Aplasia

Hra

Hereditary Urogenital Adysplasia

Hypodysplasia/Aplasia, Renal, Type 1

Congenital Absence Of Kidneys Syndrome

Congenital Absence Of Kidney

Aplastic Kidney

Retinitis Pigmentosa 55

RP55

Retinitis Pigmentosa, Type 55

Chromosome 2q35 Duplication Syndrome

Syndactyly

Syndactyly Type 1

Sdty1

Zygodactyly

Syndactyly, Type I

Sd1

Syndactyly, Type 1, With Or Without Craniosynostosis

Symphalangism

Non-Syndromic Syndactyly

Symphalangy

Webbing Of Digits

Syndactyly, Type 1

Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Cri-Du-Chat Syndrome

5p Deletion Syndrome

5p Partial Monosomy Syndrome

Monosomy 5p

Cat Cry Syndrome

Chromosome 5p Deletion Syndrome

Cri Du Chat Syndrome

5p- Syndrome

5p Minus Syndrome

Chromosome 5p- Syndrome

Chromosome 5 Short Arm Deletion Syndrome

Chromosome 5p Deletion

Deletion 5p

Cri Du Chat

5p Partial Deletion Syndrome

Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus GRIP1 MGD MGI:1921303
Bos taurus GRIP1 VGNC VGNC:56205
Felis catus GRIP1 VGNC VGNC:62714
Rattus norvegicus GRIP1 RGD RGD:621667
Macaca mulatta GRIP1 VGNC VGNC:73195
Canis familiaris GRIP1 VGNC VGNC:41498
Others GRIP1 NCBI