Gpr68 - G protein-coupled receptor 68 Gene

Mus musculus

Also known as Ogr1

Gene ID: 238377 | Gene type: protein coding

About Gpr68

Chromosome 12: 100,842,941-100,874,457 reverse strand.GRCm39:CM001005.3

This gene has 7 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 17 phenotypes. Broad expression in spleen adult (RPKM 5.7), thymus adult (RPKM 5.5) and 2 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Acts upstream of or within cellular response to pH; positive regulation of Insulin secretion involved in cellular response to glucose stimulus; and regulation of myeloid leukocyte differentiation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in early conceptus; primary oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A6. Orthologous to human GPR68 (G protein-coupled receptor 68). [provided by Alliance of Genome Resources, Apr 2022]

Gpr68 Products(4)

mRNA	Protein	Name
NM_175493.4	NP_780702.1	ovarian cancer G-protein coupled receptor 1
NM_001177673.1	NP_001171144.1	ovarian cancer G-protein coupled receptor 1
NM_001403314.1	NP_001390243.1	ovarian cancer G-protein coupled receptor 1
NM_001177674.2	NP_001171145.1	ovarian cancer G-protein coupled receptor 1

Gpr68 Protein Structure

7tmA_GPR68_OGR1

0
100
200
300
365 a.a.

Protein Preferred Names

Protein Names

ovarian cancer G-protein coupled receptor 1

sphingosylphosphorylcholine receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110279	Ogerin	Modulator	99.58%	Unkown
HY-154954	Ogremorphin	Inhibitor	99.65%	Unkown
HY-134494	MS48107		99.85%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpr68	NCBI	NCBI:8111

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