Map2k5 - mitogen-activated protein kinase kinase 5 Gene

Mus musculus

Also known as MEK5; Mapkk5; Prkmk5

Gene ID: 23938 | Gene type: protein coding

About Map2k5

Chromosome 9: 63,071,050-63,285,184 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 209 orthologues, 8 paralogues and is associated with 11 phenotypes. Ubiquitous expression in adrenal adult (RPKM 1.5), thymus adult (RPKM 8.4) and 28 other tissues.

Summary

Predicted to enable ATP binding activity and MAP kinase kinase activity. Acts upstream of or within MAPK cascade and heart development. Located in spindle. Is expressed in early conceptus; oocyte; and telencephalon. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Map2k5 Products(4)

mRNA	Protein	Name
NM_001364493.1	NP_001351422.1	dual specificity mitogen-activated protein kinase kinase 5 isoform 3
NM_001364494.1	NP_001351423.1	dual specificity mitogen-activated protein kinase kinase 5 isoform 4
NM_001364492.1	NP_001351421.1	dual specificity mitogen-activated protein kinase kinase 5 isoform 2
NM_011840.3	NP_035970.1	dual specificity mitogen-activated protein kinase kinase 5 isoform 1

Map2k5 Protein Structure

PB1_Map2k5

PKc_MKK5

0
100
200
300
400
448 a.a.

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 5

MAP kinase kinase 5

MAPK/ERK kinase 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08041	MAP2K5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08042	Map2k5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08043	Map2k5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map2k5	NCBI	NCBI:5607

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