PANX1 - pannexin 1 Gene

Homo sapiens

Also known as PX1; MRS1; OOMD7; UNQ2529

Gene ID: 24145 | Gene type: protein coding

About PANX1

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:94,128,841-94,181,968 (from NCBI)

This gene has 2 transcripts (splice variants), 274 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 7.4), appendix (RPKM 5.7) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

PANX1 Products(1)

mRNA	Protein	Name
NM_015368.4	NP_056183.2	pannexin-1

PANX1 Protein Structure

Innexin

0
100
200
300
400
426 a.a.

Protein Preferred Names

Protein Names

pannexin-1

innexin

Related Diseases

Diseases

Alias

Oocyte Maturation Defect 7

OOMD7

Oocyte Maturation Defect, Type 7

Female Infertility Due To Oocyte Meiotic Arrest

Intellectual Developmental Disorder, Autosomal Dominant 1

MRD1	Autosomal Dominant Non-Syndromic Intellectual Disability 1
Mental Retardation, Autosomal Dominant 1	Autosomal Dominant Intellectual Developmental Disorder 1

Vertebral Artery Occlusion

Occlusion And Stenosis Of Vertebral Artery

Anterior Spinal Artery Syndrome

Anterior Spinal Artery Occlusion Syndrome

Deafness, Autosomal Dominant 41

DFNA41	Autosomal Dominant Nonsyndromic Deafness 41
Autosomal Dominant Deafness 41	Deafness, Autosomal Dominant, 41
Deafness, Autosomal Dominant, Type 41

Infertility

Basilar Artery Occlusion

Oculodentodigital Dysplasia

Odd Syndrome	ODDD
Oculodentoosseous Dysplasia	Oculodentodigital Syndrome
Odod	Oculo-Dento-Digital Dysplasia
Oculo-Dento-Digital Syndrome	Oculo-Dento-Osseous Dysplasia
Osseous-Oculo-Dental Dysplasia	Meyer-Schwickerath Syndrome
Oddd Syndrome	Oculo Dento Digital Dysplasia
Odds	Oculodentodigital Dysplasia Syndrome

Jejunoileitis

Migraine, Familial Hemiplegic, 1

FHM1	Mhp1
Fhm	Familial Hemiplegic Migraine 1
Migraine, Familial Hemiplegic, 1, With Progressive Cerebellar Ataxia	Familial Hemiplegic Migraine1 With Progressive Cerebellar Ataxia
Migraine Familial Hemiplegic With Progressive Cerebellar Ataxia	Migraine, Hemiplegic, Familial, Type 1
Hemiplegic Migraine, Familial Type 1

Occlusion Precerebral Artery

Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries

Occlusion And Stenosis Of Precerebral Artery

Cerebral Arterial Disease

Cerebral Arterial Diseases

Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage	Familial Berry Aneurysm
Familial Intracranial Saccular Aneurysm	Saccular Cerebral Aneurysm
Aneurysm, Intracranial Berry	Aneurysmal Subarachnoid Hemorrhage
Aneurysm, Intracranial Berry, 1

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103399	Trovafloxacin mesylate	Inhibitor	99.56%	Unkown
HY-A0170	Trovafloxacin	Inhibitor	98.99%	Unkown

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1588S	Carbenoxolone-d4	Inhibitor	/	Unkown
HY-RS10021	PANX1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PANX1	VGNC	VGNC:32567
Felis catus	PANX1	VGNC	VGNC:68691
Canis familiaris	PANX1	VGNC	VGNC:44254
Macaca mulatta	PANX1	VGNC	VGNC:75754
Mus musculus	PANX1	MGD	MGI:1860055
Rattus norvegicus	PANX1	RGD	RGD:735204

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