FUT2 - fucosyltransferase 2 Gene

Homo sapiens

Also known as SE; Se2; sej; SEC2; B12QTL1

Gene ID: 2524 | Gene type: protein coding

About FUT2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,695,971-48,705,951 (from NCBI)

This gene has 4 transcripts (splice variants), 110 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in duodenum (RPKM 17.4), stomach (RPKM 16.4) and 11 other tissues.

Summary

This gene is one of two encoding the galactoside 2-L-fucosyltransferase Enzyme. The encoded protein is important for the final step in the soluble ABO blood group antigen synthesis pathway. It is also involved in cell-cell interaction, cell surface expression, and cell proliferation. Mutations in this gene are a cause of the H-Bombay blood group where red blood cells lack the H antigen. [provided by RefSeq, May 2022]

FUT2 Products(2)

mRNA	Protein	Name
NM_000511.6	NP_000502.4	galactoside alpha-(1,2)-fucosyltransferase 2
NM_001097638.3	NP_001091107.1	galactoside alpha-(1,2)-fucosyltransferase 2

FUT2 Protein Structure

Glyco_transf_11

0
100
200
300
343 a.a.

Protein Preferred Names

Protein Names

galactoside alpha-(1,2)-fucosyltransferase 2

GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2

Related Diseases

Diseases

Alias

Vitamin B12 Plasma Level Quantitative Trait Locus 1

B12QTL1

Bombay Phenotype

Bombay Phenotype, Digenic

Gastroenteritis

Cholera Morbus	Infectious Colitis, Enteritis And Gastroenteritis
Enteritis Due To Astrovirus	Rotaviral Gastroenteritis
Viral Gastroenteritis Due To Rotavirus

Vestibular Nystagmus

Nystagmus Associated With Disorder Of The Vestibular System

Staphyloenterotoxemia

Staphylococcal Food Poisoning	Staphylococcal Toxaemia Due To Food
Staphyloenterotoxicosis

Gastric Body Carcinoma

Cancer Of Body Of Stomach

Carcinoma Of Body Of Stomach

Hemorrhagic Disease

Hemorrhagic Disorders	Hemorrhagic Diathesis
Hemorrhagic Diseases	Bleeding Tendency
Acquired Coagulation Factor Inhibitor Disorder	Acquired Inhibitor Of Coagulation
Antithrombinaemia	Antithromboplastinogenaemia
Circulating Anticoagulant Disorder	Haemorrhagic Disorder Due To Antithrombinaemia
Haemorrhagic Disorder Due To Excess Administered Heparin	Antithromboplastinaemia
Haemorrhagic Disorder Due To Hyperheparinemia

Cholangitis

Acute Cholangiolitis	Ascending Cholangitis
Cholangiolitis	Cholangitis Nos
Chronic Cholangiolitis	Hepatic Duct Inflammation
Acute Cholangitis	Bile Duct Inflammation

Commensal Bacterial Infectious Disease

Congenital Intrinsic Factor Deficiency

Hereditary Intrinsic Factor Deficiency	Intrinsic Factor Deficiency
Congenital Pernicious Anemia	Gastric Intrinsic Factor Deficiency
Hereditary Juvenile Megaloblastic Anemia Due To Intrinsic Factor Deficiency	Ifd
Intrinsic Factor Deficiency, Congenital, Susceptibility To	Congenital Deficiency Of Intrinsic Factor
Megaloblastic Anemia Due To Inborn Errors Of Metabolism

Otitis Media

Opsoclonus-Myoclonus Syndrome	OMS
Otitis Media, Susceptibility To	Kinsbourne Syndrome
Otitis Media, Chronic/Recurrent	Come/Rom
Ataxo-Opso-Myoclonus Syndrome	Dancing Eye Syndrome
Dancing Eye-Dancing Feet Syndrome	Oma Syndrome
Opsoclonus Myoclonus Syndrome	Opsoclonus-Myoclonus-Ataxia Syndrome
Poma Syndrome	Paraneoplastic Opsoclonus-Myoclonus
Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome	Opsoclonus Myoclonus
OM	{Otitis Media, Susceptibility To}
Infectious Otitis Media

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Scarlet Fever

Scarlatina

Scarlatina Nos

Spontaneous Ocular Nystagmus

Visual Deprivation Nystagmus	Ocular Nystagmus
Searching Eye Movements	Nystagmus, Pathologic

Perinatal Necrotizing Enterocolitis

Necrotizing Enterocolitis	Enterocolitis Necrotizing
Enterocolitis, Necrotizing	Necrotizing Enterocolitis In Fetus Or Newborn
Perinatal Necrotising Enterocolitis	Pseudomembranous Enterocolitis In Newborn
Nec

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05153	FUT2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FUT2	MGD	MGI:109374
Canis familiaris	FUT2	VGNC	VGNC:53718
Rattus norvegicus	FUT2	RGD	RGD:2639