FUT3 - fucosyltransferase 3 (Lewis blood group) Gene

Homo sapiens

Also known as LE; Les; FT3B; CD174; FucT-III

Gene ID: 2525 | Gene type: protein coding

About FUT3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,842,888-5,857,122 (from NCBI)

This gene has 10 transcripts (splice variants), 384 orthologues, 7 paralogues and is associated with 1 phenotype. Biased expression in colon (RPKM 29.8), esophagus (RPKM 25.0) and 7 other tissues.

Summary

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and Bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor Polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an Enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral Infection. [provided by RefSeq, Aug 2020]

FUT3 Products(12)

mRNA	Protein	Name
NM_000149.4	NP_000140.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001097639.3	NP_001091108.3	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001097640.3	NP_001091109.3	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001097641.3	NP_001091110.3	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001374740.1	NP_001361669.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382744.1	NP_001369673.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382745.1	NP_001369674.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382746.1	NP_001369675.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382747.1	NP_001369676.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382748.2	NP_001369677.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382749.2	NP_001369678.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382750.2	NP_001369679.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

FUT3 Protein Structure

Glyco_transf_10

0
100
200
300
361 a.a.

Protein Preferred Names

Protein Names

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase 3

Related Diseases

Diseases

Alias

Blood Group, Lewis System

LE	Lewis Blood Group System
Les

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach