2. Gene
  3. Casp3 - caspase 3 Gene

Casp3 - caspase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Lice; Yama; CPP32-beta

Gene ID: 25402 | Gene type: protein coding

About Casp3

Primary_assembly 16: 45,662,910-45,684,648 reverse strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 334 orthologues, 12 paralogues and is associated with 107 phenotypes. Biased expression in Thymus (RPKM 222.5), Spleen (RPKM 187.9) and 9 other tissues.

Summary

Enables several functions, including death receptor binding activity; Phospholipase A2 activator activity; and protease binding activity. Involved in several processes, including luteolysis; nervous system development; and positive regulation of amyloid-beta formation. Located in cytosol; membrane raft; and neuronal cell body. Part of death-inducing signaling complex. Used to study artery disease (multiple); brain disease (multiple); and pre-malignant neoplasm. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); diabetes mellitus (multiple); heart disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; lung non-small cell carcinoma; and stomach Cancer. Orthologous to human CASP3 (Caspase 3). [provided by Alliance of Genome Resources, Apr 2022]

Casp3 Products(1)

mRNA Protein Name
NM_012922.2 NP_037054.1 caspase-3

Casp3 Protein Structure

CASc

CASc: smart00115 (36 - 276)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

caspase-3

CASP-3

CPP-32

CPP32beta

Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease)

IRP

SCA-1

SREBP cleavage activity 1

apopain

cysteine protease CPP32

cysteine protease p32-beta

protein Yama

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01952 CASP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01953 Casp3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01954 Casp3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp3 NCBI NCBI:836