NAALADL2 - N-acetylated alpha-linked acidic dipeptidase like 2 Gene

Homo sapiens

Gene ID: 254827 | Gene type: protein coding

About NAALADL2

Cytogenetic location: 3q26.31 Genomic coordinates (GRCh38): 3:174,440,982-175,810,548 (from NCBI)

This gene has 12 transcripts (splice variants), 184 orthologues and 5 paralogues. Ubiquitous expression in prostate (RPKM 1.4), gall bladder (RPKM 1.0) and 24 other tissues.

Summary

Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within response to bacterium. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NAALADL2 Products(1)

mRNA	Protein	Name
NM_207015.3	NP_996898.2	inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2

NAALADL2 Protein Structure

Peptidase_M28

0
200
400
600
795 a.a.

Protein Preferred Names

Protein Names

inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2

N-acetylated alpha-linked acidic dipeptidase 2

Recombinant NAALADL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71559	NAALADL2 Protein, Human (His-SUMO)	Q58DX5 (143G-795N)	≥95%

Related Diseases

Diseases

Alias

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Chromosome 6pter-P24 Deletion Syndrome

6p Subtelomeric Deletion Syndrome	6p25 Microdeletion Syndrome
Distal Monosomy 6p	Distal Deletion 6p
Monosomy 6p25

Facial Clefting, Oblique, 1

Oculomaxillofacial Dysostosis	Oculomaxillofacial Dysplasia With Oblique Facial Clefts
OBLFC1	Oblique Facial Clefting 1
Tessier Number 4 Facial Cleft	Oblique Facial Cleft
Orbitofacial Cleft	Oblique Facial Clefts
Richieri Costa Gorlin Syndrome	Richieri-Costa-Gorlin Syndrome
Facial Clefting, Oblique, Type 1

Teebi Hypertelorism Syndrome 1

Teebi Hypertelorism Syndrome	Brachycephalofrontonasal Dysplasia
Hypertelorism, Teebi Type	TBHS1
Tbhs	Chromosome 22q11.2 Deletion Syndrome, Opitz Phenotype
Opitz Gbbb Syndrome Type Ii	Specc1l-Related Hypertelorism Syndrome
Opitz Gbbb Syndrome, Type Ii, Formerly	Gbbb2, Formerly
Opitz Bbbg Syndrome, Type Ii, Formerly	Bbbg2, Formerly
Opitz-G Syndrome, Type Ii, Formerly	Ogs2, Formerly
Opitz Bbb Syndrome, Type Ii, Formerly	Hypertelorism-Hypospadias Syndrome, Formerly
Hypertelorism With Esophageal Abnormality And Hypospadias, Formerly	Opitz Oculogenitolaryngeal Syndrome, Type Ii, Formerly
Opitz-Frias Syndrome, Formerly	Teebi Hypertelorism Syndrome-1
Craniofrontonasal Dysplasia, Teebi Type	Bbb Syndrome
Gbbb Syndrome	G Syndrome
Hypertelorism-Hypospadias Syndrome	Hypertelorism With Esophageal Abnormality And Hypospadias
Hypospadias-Dysphagia Syndrome	Ogs2
Opitz Bbbg Syndrome	Opitz-Frias Syndrome
Opitz Gbbb Syndrome, Autosomal Dominant	Opitz-G Syndrome, Type Ii
Opitz Oculogenitolaryngeal Syndrome, Type Ii	Opitz Gbbb Syndrome, Type Ii
Teebi Syndrome	Opitz-G Syndrome, Type 2
Opitz Gbbb Syndrome, X-Linked	Digeorge Syndrome

Heart Aneurysm

Cardiac Aneurysm

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08995	NAALADL2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NAALADL2	VGNC	VGNC:43599
Felis catus	NAALADL2	VGNC	VGNC:102784
Bos taurus	NAALADL2	VGNC	VGNC:106832
Rattus norvegicus	NAALADL2	RGD	RGD:1565147
Mus musculus	NAALADL2	MGD	MGI:2685867
Macaca mulatta	NAALADL2	VGNC	VGNC:83927
Others	NAALADL2	NCBI

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