2. Gene
  3. Prkaca - protein kinase cAMP-activated catalytic subunit alpha Gene

Prkaca - protein kinase cAMP-activated catalytic subunit alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as PKCA1; Cs-PKA

Gene ID: 25636 | Gene type: protein coding

About Prkaca

Primary_assembly 19: 24,155,090-24,178,430 reverse strand.mRatBN7.2:CM026992.1

This gene has 5 transcripts (splice variants), 289 orthologues, 4 paralogues and is associated with 13 phenotypes. Biased expression in Heart (RPKM 789.1), Adrenal (RPKM 386.4) and 9 other tissues.

Summary

Enables cAMP-dependent protein kinase activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including circadian sleep/wake cycle, REM sleep; regulation of glutamatergic synaptic transmission; and spontaneous exocytosis of neurotransmitter. Located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and presynapse. Part of cAMP-dependent protein kinase complex. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Prkaca Products(1)

mRNA Protein Name
NM_001100922.2 NP_001094392.1 cAMP-dependent protein kinase catalytic subunit alpha

Prkaca Protein Structure

STKc_PKA

STKc_PKA: cd14209 (41 - 330)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

cAMP-dependent protein kinase catalytic subunit alpha

PKA C-alpha

cAMP-dependent protein kinase catalytic subunit C alpha

protein kinase A

protein kinase, cAMP-dependent, alpha catalytic subunit

protein kinase, cAMP-dependent, catalytic, alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150076 BLU2864 Inhibitor 99.24% Unkown
HY-150072 DS89002333 Inhibitor 99.87% Unkown
HY-150072B (R)-DS89002333 98.74% Unkown
HY-153967 BLU0588 Inhibitor 95.92% Unkown
HY-150072A (2S,4R)-DS89002333 / Unkown
HY-150073 DS01080522 Inhibitor / Unkown
HY-RS11104 PRKACA Human Pre-designed siRNA Set A / Unkown
HY-RS11105 Prkaca Mouse Pre-designed siRNA Set A / Unkown
HY-RS11106 Prkaca Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkaca NCBI NCBI:5566
Canis familiaris Prkaca NCBI NCBI:403556