SERINC5 - serine incorporator 5 Gene

Homo sapiens

Also known as TPO1; C5orf12

Gene ID: 256987 | Gene type: protein coding

About SERINC5

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:80,111,225-80,256,048 (from NCBI)

This gene has 6 transcripts (splice variants), 215 orthologues and 4 paralogues. Broad expression in testis (RPKM 21.2), colon (RPKM 21.1) and 24 other tissues.

Summary

Predicted to enable L-serine transmembrane transporter activity. Involved in defense response to virus; detection of virus; and innate immune response. Located in several cellular components, including centrosome; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SERINC5 Products(3)

mRNA	Protein	Name
NM_001174071.3	NP_001167542.1	serine incorporator 5 isoform 3
NM_001174072.3	NP_001167543.1	serine incorporator 5 isoform 1
NM_178276.7	NP_840060.1	serine incorporator 5 isoform 2

SERINC5 Protein Structure

Serinc

0
100
200
300
400
456 a.a.

Protein Preferred Names

Protein Names

serine incorporator 5

Related Diseases

Diseases

Alias

Hawkinsinuria

4-Alpha-Hydroxyphenylpyruvate Hydroxylase Deficiency	4-Hppd Deficiency
4-Hydroxyphenylpyruvic Acid Dioxygenase Deficiency	HWKS
HAWK

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12693	SERINC5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SERINC5	VGNC	VGNC:34463
Rattus norvegicus	SERINC5	RGD	RGD:621571
Mus musculus	SERINC5	MGD	MGI:2444223
Canis familiaris	SERINC5	VGNC	VGNC:46022
Macaca mulatta	SERINC5	VGNC	VGNC:77271
Felis catus	SERINC5	VGNC	VGNC:65020

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