2. Gene
  3. GCA - grancalcin Gene

GCA - grancalcin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GCL

Gene ID: 25801 | Gene type: protein coding

About GCA

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:162,318,763-162,375,396 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 20 paralogues. Broad expression in bone marrow (RPKM 47.3), appendix (RPKM 18.4) and 18 other tissues.

Summary

This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Aug 2016]

GCA Products(7)

mRNA Protein Name
NM_001330265.1 NP_001317194.1 grancalcin isoform a
NM_001330266.1 NP_001317195.1 grancalcin isoform a
NM_001330267.1 NP_001317196.1 grancalcin isoform a
NM_001330268.1 NP_001317197.1 grancalcin isoform c
NM_001330270.2 NP_001317199.1 grancalcin isoform d
NM_001330271.2 NP_001317200.1 grancalcin isoform d
NM_012198.5 NP_036330.1 grancalcin isoform b

GCA Protein Structure

EF-hand_8

EF-hand_8: EF-hand domain pair (64 - 119)

EF-hand_6

EF-hand_6: EF-hand domain (125 - 150)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

grancalcin

grancalcin, EF-hand calcium-binding protein

Recombinant GCA Proteins

Cat. No. Product Name Accession Purity
HY-P70334 Grancalcin/GCA Protein, Human (His) P28676 (M1-I217) ≥95%
HY-P72635 Grancalcin/GCA Protein, Human (GST) P28676 (M1-I217) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-143230 Custirsen 98.71% Phase 3
HY-142118 Trabedersen Inhibitor 90.45% Phase 3
HY-132596 Tivanisiran Inhibitor / Phase 3
HY-145728 Alicaforsen Inhibitor / Phase 3
HY-148100 Emapticap pegol / Phase 2
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100540 Golgicide A Inhibitor 99.85% Unkown
HY-100540B Golgicide A-2 Inhibitor 99.53% Unkown
HY-100540C Golgicide A-1 99.68% Unkown
HY-100540A (Rac)-Golgicide A Inhibitor / Unkown
HY-116528 GCA-186 Inhibitor / Unkown
HY-149453 MCUF-651 Modulator / Unkown
HY-150213 ODN BW001 Inhibitor / Unkown
HY-RS05317 GCA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GCA MGD MGI:1918521
Macaca mulatta GCA VGNC VGNC:72726
Canis familiaris GCA VGNC VGNC:41137
Rattus norvegicus GCA RGD RGD:1306589
Felis catus GCA VGNC VGNC:80217
Bos taurus GCA VGNC VGNC:29278
Others GCA NCBI