MYRIP - myosin VIIA and Rab interacting protein Gene

Homo sapiens

Also known as SLAC2C; SLAC2-C

Gene ID: 25924 | Gene type: protein coding

About MYRIP

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:39,808,914-40,260,321 (from NCBI)

This gene has 10 transcripts (splice variants), 116 orthologues and 2 paralogues. Broad expression in brain (RPKM 7.4), spleen (RPKM 4.2) and 23 other tissues.

Summary

Predicted to enable actin binding activity and Myosin binding activity. Predicted to be involved in positive regulation of Insulin secretion. Predicted to be located in actin cytoskeleton; dense core granule; and perinuclear region of cytoplasm. Predicted to be part of exocyst. Predicted to be active in cortical actin Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

MYRIP Products(5)

mRNA	Protein	Name
NM_001284423.2	NP_001271352.1	rab effector MyRIP isoform a
NM_001284424.2	NP_001271353.1	rab effector MyRIP isoform b
NM_001284425.2	NP_001271354.1	rab effector MyRIP isoform c
NM_001284426.2	NP_001271355.1	rab effector MyRIP isoform d
NM_015460.4	NP_056275.2	rab effector MyRIP isoform a

MYRIP Protein Structure

FYVE_2

Rab_eff_C

0
200
400
600
800
859 a.a.

Protein Preferred Names

Protein Names

rab effector MyRIP

Slp homologue lacking C2 domains

Related Diseases

Diseases

Alias

Deafness, Autosomal Dominant 50

DFNA50	Autosomal Dominant Nonsyndromic Deafness 50
Autosomal Dominant Deafness 50	Deafness, Autosomal Dominant, Type 50

Griscelli Syndrome

Chediak-Higashi-Like Syndrome	Griscelli-Prunieras Syndrome
Partial Albinism-Immunodeficiency Syndrome	Griscelli Disease
Gs	Hypopigmentation Immunodeficiency Disease
Partial Albinism With Immunodeficiency	Immunodeficiency Syndrome With Hypopigmentation
Hypopigmentation-Immunodeficiency Disease

Cerebrooculofacioskeletal Syndrome 1

Cofs Syndrome	COFS1
Pena-Shokeir Syndrome Type 2	Cofs
Pena-Shokeir Syndrome, Type Ii	Cerebrooculofacioskeletal Syndrome
Cerebro-Oculo-Facio-Skeletal Syndrome 1	Pena Shokeir Syndrome Type 2

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08971	MYRIP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MYRIP	MGD	MGI:2384407
Felis catus	MYRIP	VGNC	VGNC:102783
Bos taurus	MYRIP	VGNC	VGNC:31846
Macaca mulatta	MYRIP	VGNC	VGNC:74992
Rattus norvegicus	MYRIP	RGD	RGD:727731
Canis familiaris	MYRIP	VGNC	VGNC:43589

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