SOSTDC1 - sclerostin domain containing 1 Gene

Homo sapiens

Also known as DAND7; USAG1; CDA019; ECTODIN

Gene ID: 25928 | Gene type: protein coding

About SOSTDC1

Cytogenetic location: 7p21.2 Genomic coordinates (GRCh38): 7:16,461,481-16,465,738 (from NCBI)

This gene has 2 transcripts (splice variants), 127 orthologues and 1 paralogue. Biased expression in lung (RPKM 31.5), stomach (RPKM 24.1) and 9 other tissues.

Summary

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]

SOSTDC1 Products(1)

mRNA	Protein	Name
NM_015464.3	NP_056279.1	sclerostin domain-containing protein 1 precursor

SOSTDC1 Protein Structure

Sclerostin

0
100
206 a.a.

Protein Preferred Names

Protein Names

sclerostin domain-containing protein 1

cystine-knot containing secreted protein

Recombinant SOSTDC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78765	USAG-1 Protein, Human (HEK293, Fc)	Q6X4U4-1 (F24-S206)	≥95%
HY-P79179	USAG1 Protein, Human	NP_056279 (F24-S206)	≥95%

Related Diseases

Diseases

Alias

Sclerosteosis

Cortical Hyperostosis With Syndactyly	Sost
Cortical Hyperostosis-Syndactyly Syndrome

Renal Fibrosis

Sclerosteosis 1

SOST1	Sost
Cortical Hyperostosis With Syndactyly	Sclerosteosis
Sclerosteosis, Type 1

Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive

Hypohidrotic Ectodermal Dysplasia	Hed
Anhidrotic Ectodermal Dysplasia	Ectodermal Dysplasia, Hypohidrotic
Eda	Christ-Siemens-Touraine Syndrome
ECTD10B	Ectodermal Dysplasia Anhidrotic
Ectodermal Dysplasia, Anhidrotic	Cst Syndrome
Ectodermal Dysplasia Hypohidrotic Autosomal Recessive	Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive
Dysplasia, Ectodermal, Hypohidrotic	Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive
Ectodermal Dysplasia 3, Anhidrotic	Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13579	SOSTDC1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SOSTDC1	MGD	MGI:1913292
Felis catus	SOSTDC1	VGNC	VGNC:80722
Canis familiaris	SOSTDC1	VGNC	VGNC:46668
Macaca mulatta	SOSTDC1	VGNC	VGNC:77973
Rattus norvegicus	SOSTDC1	RGD	RGD:628877
Bos taurus	SOSTDC1	VGNC	VGNC:35136

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