1. Gene
  2. GPSM1 - G protein signaling modulator 1 Gene

GPSM1 - G protein signaling modulator 1 Gene

Homo sapiens

Also known as AGS3

Gene ID: 26086 | Gene type: protein coding

About GPSM1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,327,539-136,359,601 (from NCBI)

This gene has 6 transcripts (splice variants), 219 orthologues and 6 paralogues. Broad expression in brain (RPKM 5.1), testis (RPKM 4.7) and 24 other tissues.

Summary

G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GPSM1 Products(5)

mRNA Protein Name
NM_001145638.3 NP_001139110.2 G-protein-signaling modulator 1 isoform a
NM_001145639.2 NP_001139111.1 G-protein-signaling modulator 1 isoform c
NM_001200003.2 NP_001186932.1 G-protein-signaling modulator 1 isoform c
NM_001412257.1 NP_001399186.1 G-protein-signaling modulator 1 isoform d
NM_015597.6 NP_056412.5 G-protein-signaling modulator 1 isoform b

GPSM1 Protein Structure

TPR_1

TPR_1: Tetratricopeptide repeat (68 - 89)

TPR_12

TPR_12: Tetratricopeptide repeat (109 - 162)

TPR_7

TPR_7: Tetratricopeptide repeat (211 - 245)

TPR_12

TPR_12: Tetratricopeptide repeat (250 - 316)

GoLoco

GoLoco: GoLoco motif (496 - 517)

GoLoco

GoLoco: GoLoco motif (548 - 569)

GoLoco

GoLoco: GoLoco motif (597 - 617)

GoLoco

GoLoco: GoLoco motif (630 - 652)

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  • 675 a.a.
Protein Preferred Names Protein Names

G-protein-signaling modulator 1

G-protein signalling modulator 1 (AGS3-like, C. elegans)

Related Diseases

Diseases Alias
Peroxisome Biogenesis Disorder 2a

PBD2A

Peroxisome Biogenesis Disorder Complementation Group 2

PBD-CG2

Cg1

Pbd-Cge

Peroxisome Biogenesis Disorder Complementation Group E

Peroxisome Biogenesis Disorder, Type 2a

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus GPSM1 VGNC VGNC:62697
Bos taurus GPSM1 VGNC VGNC:29614
Macaca mulatta GPSM1 VGNC VGNC:72960
Mus musculus GPSM1 MGD MGI:1915089
Rattus norvegicus GPSM1 RGD RGD:628682
Canis familiaris GPSM1 VGNC VGNC:41457