HERC4 - HECT and RLD domain containing E3 ubiquitin protein ligase 4 Gene

Homo sapiens

Gene ID: 26091 | Gene type: protein coding

About HERC4

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:67,921,905-68,075,283 (from NCBI)

This gene has 15 transcripts (splice variants), 201 orthologues and 24 paralogues. Ubiquitous expression in lymph node (RPKM 8.1), adrenal (RPKM 7.4) and 25 other tissues.

Summary

HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

HERC4 Products(5)

mRNA	Protein	Name
NM_001278185.2	NP_001265114.1	probable E3 ubiquitin-protein ligase HERC4 isoform c
NM_001278186.2	NP_001265115.1	probable E3 ubiquitin-protein ligase HERC4 isoform d
NM_001278187.2	NP_001265116.1	probable E3 ubiquitin-protein ligase HERC4 isoform e
NM_015601.4	NP_056416.2	probable E3 ubiquitin-protein ligase HERC4 isoform b
NM_022079.3	NP_071362.1	probable E3 ubiquitin-protein ligase HERC4 isoform a

HERC4 Protein Structure

RCC1

HECT

0
200
400
600
800
1000
1057 a.a.

Protein Preferred Names

Protein Names

probable E3 ubiquitin-protein ligase HERC4

HECT domain and RCC1-like domain-containing protein 4

Related Diseases

Diseases

Alias

Osteonecrosis Of The Jaw

Balantidiasis

Balantidiosis	Human Balantidiasis
B Coli Infection	Balantidium Coli Infection
Large-Intestinal Infection With Balantidium Coli	Ciliary Dysentery

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06129	HERC4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HERC4	VGNC	VGNC:51899
Felis catus	HERC4	VGNC	VGNC:107057
Rattus norvegicus	HERC4	RGD	RGD:1310971
Bos taurus	HERC4	VGNC	VGNC:55988
Mus musculus	HERC4	MGD	MGI:1914595
Macaca mulatta	HERC4	VGNC	VGNC:106056

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